Virulence and Resistance to Antifungal Therapies of Scopulariopsis Species

Antimicrobial Agents and Chemotherapy
Katihuska ParedesJosep Guarro

Abstract

Scopulariopsisis an emerging opportunistic fungus characterized by its high resistance to antifungal therapies. We have developed a murine model of disseminated infection in immunosuppressed animals by intravenous inoculation ofScopulariopsis brevicaulisandScopulariopsis brumptii, the most clinically relevant species, in order to evaluate their virulence and their responses to conventional antifungal treatments. Survival and tissue burden studies showed thatS. brumptiiwas more virulent thanS. brevicaulis The three drugs tested, liposomal amphotericin B, posaconazole, and voriconazole, prolonged the survival of mice infected withS. brumptii, but none showed efficacy againstS. brevicaulis The different therapies were only able to modestly reduce the fungal burden of infected tissue; however, in general, despite the high serum levels reached, they showed poor efficacy in the treatment of the infection. Unfortunately, the most effective therapy forScopulariopsisinfections remains unresolved.

References

May 29, 1999·Antimicrobial Agents and Chemotherapy·C AguilarJ Guarro
Jan 5, 2000·Journal of Clinical Microbiology·J W BaddleyP G Pappas
Feb 13, 2001·Antimicrobial Agents and Chemotherapy·A M Sugar, X P Liu
Jul 27, 2001·Veterinary Pathology·P HerráezR Dunstan
May 26, 2006·Antimicrobial Agents and Chemotherapy·Manuel Cuenca-EstrellaJuan L Rodriguez-Tudela
Apr 3, 2007·The Journal of Antimicrobial Chemotherapy·Peter J SmithJill P Adler-Moore
Feb 7, 2009·Acta Dermato-venereologica·Ching-Ying WuChieh-Shan Wu
Mar 12, 2010·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Peter G PappasTom M Chiller
Mar 12, 2010·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Dimitrios P KontoyiannisPeter G Pappas
May 22, 2010·The Journal of Antimicrobial Chemotherapy·Enrique CalvoJosep Guarro
Apr 16, 2011·The Journal of Antimicrobial Chemotherapy·Josep Guarro
May 3, 2011·The Lancet Infectious Diseases·Arnaud PetitAdela Angoulvant
May 29, 2012·Diagnostic Microbiology and Infectious Disease·Qing YangZhenjing Chen
Feb 20, 2014·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·A M TortoranoC Lass-Flörl
Sep 4, 2014·Antimicrobial Agents and Chemotherapy·Russell E LewisDimitrios P Kontoyiannis
Nov 8, 2014·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·C M ShaverI M Robbins
Jun 24, 2015·Antimicrobial Agents and Chemotherapy·Magdalena SkóraTomasz Jagielski
Sep 13, 2016·Persoonia·M Sandoval-DenisJ Guarro

❮ Previous
Next ❯

Citations

Dec 30, 2016·Fetal and Pediatric Pathology·Louise Helander, Matthew Stark
Apr 4, 2018·Mycoses·Oliver A CornelyGalia Rahav
Jul 23, 2019·Medical Mycology·Alba Pérez-Cantero, Josep Guarro
May 22, 2019·Medical Mycology·Sarah DellièreAlexandre Alanio

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Aspergillosis

Aspergillosis is the name given to a wide variety of diseases caused by infection by fungi of the genus Aspergillus. Aspergillosis occurs in chronic or acute forms which are clinically very distinct. Most cases of acute aspergillosis occur in patients with severely compromised immune systems. Chronic colonization or infection can cause complications in people with underlying respiratory illnesses. Discover the latest research on aspergillosis here.

Aspergillosis (ASM)

Aspergillosis is the name given to a wide variety of diseases caused by infection by fungi of the genus Aspergillus. Aspergillosis occurs in chronic or acute forms which are clinically very distinct. Most cases of acute aspergillosis occur in patients with severely compromised immune systems. Chronic colonization or infection can cause complications in people with underlying respiratory illnesses. Discover the latest research on aspergillosis here.

CRISPR Screens in Drug Resistance

CRISPR-Cas system enables the editing of genes to create or correct mutations. This feed focuses on the application of CRISPR-Cas system in high-throughput genome-wide screens to identify genes that may confer drug resistance.

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.