Virulence as a Side Effect of Interspecies Interaction in Vibrio Coral Pathogens.

MBio
Esther Rubio-PortilloJosefa Antón

Abstract

The increase in prevalence and severity of coral disease outbreaks produced by Vibrio pathogens, and related to global warming, has seriously impacted reef-building corals throughout the oceans. The coral Oculina patagonica has been used as a model system to study coral bleaching produced by Vibrio infection. Previous data demonstrated that when two coral pathogens (Vibrio coralliilyticus and Vibrio mediterranei) simultaneously infected the coral O. patagonica, their pathogenicity was greater than when each bacterium was infected separately. Here, to understand the mechanisms underlying this synergistic effect, transcriptomic analyses of monocultures and cocultures as well as experimental infection experiments were performed. Our results revealed that the interaction between the two vibrios under culture conditions overexpressed virulence factor genes (e.g., those encoding siderophores, the type VI secretion system, and toxins, among others). Moreover, under these conditions, vibrios were also more likely to form biofilms or become motile through induction of lateral flagella. All these changes that occur as a physiological response to the presence of a competing species could favor the colonization of the host when they are pr...Continue Reading

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Jul 30, 2020·Nature Reviews. Microbiology·Andrea Du Toit
May 18, 2021·Royal Society Open Science·Emma R KelleyRachel M Wright
Nov 12, 2021·Frontiers in Cellular and Infection Microbiology·Fabián GalvisMiguel Balado

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Datasets Mentioned

BETA
PRJNA632837
PRJNA632838
PRJNA609971
MSV000083610

Software Mentioned

CheckM
Prinseq
TIGRFAM
cast
ARB
cmsearch
MZmine
Metabolome
DEseq
BLASTn

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