Virulence characteristics of Klebsiella and clinical manifestations of K. pneumoniae bloodstream infections.

Emerging Infectious Diseases
Victor L YuInternational Klebseilla Study Group

Abstract

We studied 455 consecutive episodes of Klebsiella pneumoniae bacteremia occurring in 7 countries. Community-acquired pneumonia and an invasive syndrome of liver abscess, meningitis, or endophthalmitis occurred only in Taiwan and South Africa. Infections by K1 and K2 capsular serotype, the mucoid phenotype, and aerobactin production were important determinants of virulence. The mucoid phenotype was seen in 94% of isolates in patients with community-acquired pneumonia and in 100% of isolates that caused the invasive syndrome in Taiwan and South Africa, compared with only 2% of isolates elsewhere. Mortality of mice injected with mucoid strains (69%) was strikingly higher than that occurring in mice injected with nonmucoid strains (3%, p < 0.001). Differences in clinical features of bacteremic infection with K. pneumoniae are due to the virulence factors expressed by the organism.

References

Oct 1, 1978·The Journal of Hygiene·J M Palfreyman
Feb 1, 1991·Southern Medical Journal·J A KorvickR R Muder
Jan 1, 1991·Respiratory Medicine·J M HammondA A Forder
Jul 1, 1990·Reviews of Infectious Diseases·J L Carpenter
Feb 1, 1989·Infection and Immunity·X NassifP J Sansonetti
Jun 1, 1988·American Journal of Infection Control·J S GarnerJ M Hughes
Oct 1, 1988·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·S H JacobsonA Brauner
Dec 1, 1996·Intensive Care Medicine·A Torres, M el-Ebiary
May 1, 1996·Current Opinion in Pulmonary Medicine·H A Cassiere, A M Fein
Jun 24, 1998·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·J H WangH H Lin
Sep 7, 2000·Diagnostic Microbiology and Infectious Disease·S C ChangK T Luh
Mar 19, 2002·Emerging Infectious Diseases·Wen-Chien KoVictor L Yu

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Citations

May 25, 2010·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·T-Y ChuangP-R Hsueh
May 28, 2010·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·Y-T LinC-P Fung
Jun 21, 2012·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Susan Shin-Jung Lee
Aug 21, 2013·The Journal of Antimicrobial Chemotherapy·Chun-Hsing LiaoDavid C Hooper
Nov 17, 2009·Respirology : Official Journal of the Asian Pacific Society of Respirology·Jeremy S Brown
Jun 17, 2011·Journal of Clinical Microbiology·Dominique DecréGuillaume Arlet
Jan 11, 2013·Journal of Clinical Microbiology·Darpun D SachdevAdam J Ratner
Jul 11, 2012·BMC Microbiology·Diana P CruzMaría Mercedes Zambrano
Jul 14, 2011·Emerging Infectious Diseases·Chun-Hsing LiaoPo-Ren Hseuh
Aug 26, 2010·Emerging Infectious Diseases·Robert McCabeBrad Frazee
Jul 31, 2012·Emerging Infectious Diseases·Chang-Phone FungL Kristopher Siu
Sep 10, 2013·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·C H LiaoP R Hsueh
Apr 8, 2009·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Rosanne E FrederickJennifer L DuBois
Oct 4, 2013·Journal of Clinical Microbiology·Sylvain BrisseDominique Decré
Dec 14, 2011·Journal of Microbiology, Immunology, and Infection = Wei Mian Yu Gan Ran Za Zhi·Tzu-Yi ChuangPo-Ren Hsueh
Sep 1, 2015·Journal of the Formosan Medical Association = Taiwan Yi Zhi·Chung-Huei HuangYu-Yao Huang
May 7, 2013·Journal of Bioscience and Bioengineering·Duk-Ki KimYong Keun Chang
Jun 12, 2013·Revue des maladies respiratoires·W El KhattabiZ Bouayad
Jan 13, 2016·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·Q YanW-e Liu
Jul 20, 2010·The Surgical Clinics of North America·Kaye M Reid-LombardoGuido Sclabas
Jan 23, 2010·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Wen-Neng ChangChun-Chih Chien
Dec 3, 2009·Revue des maladies respiratoires·H BaudrandG Devouassoux
Jul 28, 2009·Diagnostic Microbiology and Infectious Disease·Roger ArgelichFrancesc Fernández-Monrás
Nov 1, 2015·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Bénédicte MelotGilles Guerrier
Aug 25, 2011·Kansenshōgaku zasshi. The Journal of the Japanese Association for Infectious Diseases·Keitaro NakamotoHajime Goto
Aug 5, 2008·Biochimica Et Biophysica Acta·Eugene D Weinberg
Oct 7, 2015·New Microbes and New Infections·C Akoua-KoffiS L Becker

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Methods Mentioned

BETA
dot blot
PCR
ELISA
Electrophoresis

Software Mentioned

PROPHET Statistics
Gel Doc

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