Virulence domain of the RYMV genome-linked viral protein VPg towards rice rymv1-2-mediated resistance

Archives of Virology
Eugénie HébrardDenis Fargette

Abstract

Virulent variants of Rice yellow mottle virus (genus Sobemovirus) can emerge on the highly resistant rice cultivars Gigante and Bekarosaka. Non-synonymous mutations responsible for the breakdown of the recessive resistance gene rymv1-2 were located in the VPg after determination of its termini in the polyprotein P2a. The secondary structure of this protein was predicted to include a central alpha-helix. The two major amino acids related to virulence are located on the same side of this helix. The 3D topology and the biochemical properties of virulence mutations both suggested a direct site-to-site interaction between RYMV VPg and rice eIF(iso)4G encoded by rymv1.

References

Feb 28, 1998·Biochimie·G DeléageC Geourjon
Nov 24, 1999·The Journal of General Virology·J J López-MoyaT P Pirone
Oct 30, 2001·Advances in Virus Research·E SadowyA L Haenni
Dec 14, 2005·Trends in Plant Science·Christophe Robaglia, Carole Caranta
May 6, 2006·Molecular Plant-microbe Interactions : MPMI·Valérie AymeBenoît Moury
Jun 16, 2006·The Plant Journal : for Cell and Molecular Biology·Laurence AlbarAlain Ghesquière
Nov 28, 2007·PLoS Pathogens·Agnès Pinel-GalziDenis Fargette

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Citations

Mar 4, 2010·TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik·Deless ThiéméléLaurence Albar
Sep 28, 2012·Molecular Plant-microbe Interactions : MPMI·C ReinboldV Brault
Feb 18, 2009·Virology Journal·Eugénie HébrardDenis Fargette
Feb 1, 2012·PLoS Pathogens·Nils PoulicardDenis Fargette
Aug 23, 2011·FEBS Letters·Allan OlspertErkki Truve
Nov 12, 2010·The Journal of General Virology·Allan OlspertErkki Truve
Jun 27, 2015·Viruses·Hélène Sanfaçon

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