Virulence factors and phylogenetic grouping of Escherichia coli isolates from patients with bacteraemia of urinary tract origin relate to sex and hospital- vs. community-acquired origin

International Journal of Medical Microbiology : IJMM
Line Skjøt-RasmussenNiels Frimodt-Møller

Abstract

Worldwide, Escherichia coli is a leading cause of bloodstream infections. Bacteraemia cases in both community- and hospital-acquired infections are often due to E. coli, and it is a major cause of mortality from these infections. These invasive infections are primarily due to extraintestinal pathogenic E. coli (ExPEC), possessing a variety of virulence factors (VFs). The pathogenesis of E. coli bloodstream infections is largely unknown, which is why preventive measures are lacking. We studied 196 epidemiologically and clinically well-characterized E. coli isolates from patients with bacteraemia of urinary tract origin according to virulence-associated genes (VAGs), phylogroups, and antimicrobial resistance, and the relation of these factors to hospital- vs. community-acquired origin, sex, and mortality. We found papAH to be associated with community-acquired (CA) rather than hospital-acquired (HA) episodes, and kpsM II and hlyD to be associated with HA rather than CA episodes. papAH and iss were associated with females, and iroN with males. Phylogroup D was associated with females. None of the variables was found to be related to mortality. This study provides new insights into the relationships between the epidemiology and pat...Continue Reading

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Citations

Nov 1, 2015·Journal of Medical Microbiology·Helen MiajlovicStephen Gj Smith
Feb 24, 2015·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·J K AbernethyR J Hope
Jul 13, 2012·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·L Skjøt-RasmussenA M Hammerum
Jan 18, 2018·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·B OwrangiM Katouli
Dec 15, 2016·Turkish Journal of Medical Sciences·Betül GiraySabire Şöhret Aydemir
Apr 20, 2017·Annals of Clinical Microbiology and Antimicrobials·Qing-Wen HeBin Li
Jun 28, 2019·Frontiers in Cellular and Infection Microbiology·Ana Paula DagaEliana Carolina Vespero
Jan 23, 2020·Brazilian Journal of Microbiology : [publication of the Brazilian Society for Microbiology]·Claudia A FreireWaldir P Elias

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