Virulence factors of Escherichia coli isolated from female reproductive tract infections and neonatal sepsis

Infectious Diseases in Obstetrics and Gynecology
S W CookR A Hull

Abstract

The presence of enterobacteria such as Escherichia coli in the vagina of normal women is not synonymous with infection. However, vaginal E. coli may also cause symptomatic infections. We examined bacterial virulence properties that may promote symptomatic female reproductive tract infections (RTI) and neonatal sepsis. E. coli isolated as the causative agent from cases of vaginitis (n = 50), tubo-ovarian abscess (n = 45) and neonatal sepsis (n = 45) was examined for selected phenotypic and genetic virulence properties. Results were compared with the frequency of the same properties among fecal E. coli not associated with disease. A significantly greater proportion of infection E. coli exhibited D-mannose resistant hemagglutination compared with fecal E. coli (p < 0.01). This adherence phenotype was associated with the presence of P fimbriae (pap) genes which were also significantly more prevalent among isolates from all three infection sites (p < 0.01). The majority of pap+ isolates contained the papG3 allele (Class II) regardless of infection type. Increased frequency of Type IC genes among vaginitis and abscess isolates was also noted. No significant differences in frequency of other bacterial adherence genes, fim, sfa, uca (g...Continue Reading

Citations

Jun 28, 2008·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·D W HilbertJ P Trama
Jan 20, 2016·The Tohoku Journal of Experimental Medicine·Zhongyuan LiXiaoping Zhang
Dec 31, 2005·Current Opinion in Microbiology·Eliora Z Ron
Jun 30, 2012·Journal of Medical Microbiology·Agnieszka KaczmarekEugenia Gospodarek
Nov 6, 2013·Postgraduate Medical Journal·Žana BumbulienėGražina Drąsutiene

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