Virulence Gene Profiles and Clonal Relationships of Escherichia coli O26:H11 Isolates from Feedlot Cattle as Determined by Whole-Genome Sequencing

Applied and Environmental Microbiology
Narjol Gonzalez-EscalonaJianghong Meng


Escherichia coli O26 is the second most important enterohemorrhagic E. coli (EHEC) serogroup worldwide. Serogroup O26 strains are categorized mainly into two groups: enteropathogenic (EPEC) O26, carrying a locus of enterocyte effacement (LEE) and mostly causing mild diarrhea, and Shiga-toxigenic (STEC) O26, which carries the Shiga toxin (STX) gene (stx), responsible for more severe outcomes. stx-negative O26 strains can be further split into two groups. One O26 group differs significantly from O26 EHEC, while the other O26 EHEC-like group shows all the characteristics of EHEC O26 except production of STX. In order to determine the different populations of O26 E. coli present in U.S. cattle, we sequenced 42 O26:H11 strains isolated from feedlot cattle and compared them to 37 O26:H11 genomes available in GenBank. Phylogenetic analysis by whole-genome multilocus sequence typing (wgMLST) showed that O26:H11/H(-) strains in U.S. cattle were highly diverse. Most strains were sequence type 29 (ST29). By wgMLST, two clear lineages could be distinguished among cattle strains. Lineage 1 consisted of O26:H11 EHEC-like strains (ST29) (4 strains) and O26:H11 EHEC strains (ST21) (2 strains), and lineage 2 (36 strains) consisted of O26:H11 EP...Continue Reading


Nov 1, 1990·Journal of Bacteriology·M LaviñaF Moreno
Jan 1, 1983·Journal of Molecular Evolution·M NeiY Tateno
Feb 11, 1998·Clinical Microbiology Reviews·J P Nataro, J B Kaper
Sep 8, 1998·Microbiology and Molecular Biology Reviews : MMBR·J Mahillon, M Chandler
Oct 30, 2001·Journal of Public Health Management and Practice : JPHMP·C D Malloy, J S Marr
Apr 15, 2005·Emerging Infectious Diseases·Josefa M RangelDavid L Swerdlow
Sep 20, 2005·The Journal of Infectious Diseases·John T BrooksNancy A Strockbine
May 13, 2006·Molecular Microbiology·Thierry WirthMark Achtman
Apr 3, 2007·Applied and Environmental Microbiology·Martina BielaszewskaHelge Karch
Jan 4, 2008·Journal of Applied Microbiology·C JenkinsG Frankel
Jun 21, 2008·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Martina BielaszewskaAlexander Mellmann
Oct 23, 2008·Nucleic Acids Research·William KlimkeTatiana Tatusova
Mar 11, 2009·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Steen EthelbergKåre Mølbak
Nov 18, 2009·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Carola VenturiniMark J Walker
Jan 5, 2011·Emerging Infectious Diseases·Elaine ScallanPatricia M Griffin
May 31, 2011·Applied and Environmental Microbiology·Lydia V RumpNarjol González-Escalona
Jun 24, 2011·The New England Journal of Medicine·Christina FrankUNKNOWN HUS Investigation Team
Dec 23, 2011·The Pediatric Infectious Disease Journal·Jennifer A BrownRichard L Vogt
Mar 2, 2012·Emerging Infectious Diseases·Margo E Chase-ToppingDavid L Gally
Jul 12, 2012·The Journal of Antimicrobial Chemotherapy·Ea ZankariMette Voldby Larsen
Feb 5, 2013·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Martina BielaszewskaHelge Karch
Oct 10, 2013·Genome Biology and Evolution·Stefan BletzAlexander Mellmann
Oct 18, 2013·Molecular Biology and Evolution·Koichiro TamuraSudhir Kumar
Dec 18, 2013·Applied and Environmental Microbiology·Masahiro KusumotoTetsuya Hayashi
Feb 28, 2014·Journal of Clinical Microbiology·Katrine Grimstrup JoensenFrank M Aarestrup
Aug 26, 2014·Emerging Infectious Diseases·Lothar BeutinEckhard Strauch

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