PMID: 8981347Jan 1, 1996Paper

Virulence in mice of Orientia tsutsugamushi isolated from patients in a new endemic area in Japan

Microbiology and Immunology
I NaganoT Yamashita

Abstract

Four strains of Orientia tsutsugamushi (KN-1, KN-2, KN-3 and GJ-1) isolated from patients in an area of Gifu Prefecture, Japan, in which tsutsugamushi disease is newly endemic, were examined for their virulence in mice. Among these, KN-1 (identified as Kawasaki type), GJ-1 (identified as Kuroki type) and KN-2 strains were found to be non-lethal for BALB/c mice as well as CH3/HeJ mice, even with high doses (10(6) x being the 50% mouse infectious dose). On the other hand, the KN-3 strain was found to be sufficiently virulent to kill BALB/c mice. Among the prototype strains (Gilliam, Karp and Kato), the Karp and Kato strains exhibited high virulence to mice, while the Gilliam strain killed only a susceptible strain of mouse. BALB/c mice infected with KN-1 and KN-2 strains showed significant splenomegaly and moderate ascites accumulation in the first week of infection, while these symptoms became prominent during the second week of infection using KN-3, Karp and Kato strains. After infection with the GJ-1 strain, these symptoms were not observed. Antibody responses induced by infections with highly virulent strains were lower than that with low or intermediate virulent strains.

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Citations

Feb 15, 2003·The Pediatric Infectious Disease Journal·Kyung-Yil LeeKyung-Tai Whang
Jun 15, 2013·Emerging Infectious Diseases·Meng ZhangHui-Li Yang
Oct 24, 2012·The American Journal of Tropical Medicine and Hygiene·Meng ZhangShu-Jun Ding
Sep 16, 2015·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Li ZhengZhongtang Zhao
Sep 26, 2020·The American Journal of Tropical Medicine and Hygiene·Hiroaki KikuchiKazuaki Shinohara
Dec 15, 2020·Acta Tropica·Seok Won KimByeong Jeon Yu
Feb 22, 2021·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Hitomi KinoshitaShuji Ando

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