PMID: 1208567Nov 1, 1975Paper

Virulence of Streptococcus mutans: biochemical and pathogenic characteristics of mutant isolates

Proceedings of the Society for Experimental Biology and Medicine
S M MichalekJ R McGhee

Abstract

The in vitro dextran-sucrase activities and adherence to glass of S. mutans 6715 and PS14 wild types and mutants were quantitated and compared with their in vivo cariogenicity in young, gnotobiotic rats. In general, S. mutans PS14 mutants B414 and B421 and 6715 mutant C4 demonstrated less dextran-sucrase activity and adherence than parental strains and caused fewer carious lesions in gnotobiotic rats. Rats monoinfected with either PS14 mutants B414 or B421 had less plaque and viable S. mutans in plaque than rats infected with parental strain. Both S. mutans 6715 mutants C211 and C229, demonstrated greater enzyme activity and adherence than the parental strain and produced more carious lesions.

Citations

Apr 1, 1985·Scandinavian Journal of Dental Research·C G Emilson, B Krasse
Feb 1, 1978·Journal of Dental Research·G S SchusterR H Larson
Oct 1, 1980·Journal of Dental Research·M W Mao, S Rosen
Feb 1, 1977·Infection and Immunity·S M MichalekD Devenyns
Jun 1, 1984·Applied and Environmental Microbiology·T W Feary, J A Mayo
Jan 1, 1978·Journal of Bacteriology·C L WittenbergerL N Lee
Feb 1, 1982·Infection and Immunity·M L FreedmanE M O'Neill
Jan 1, 1980·Infection and Immunity·T IkedaT Shiota
Dec 1, 1986·Microbiological Reviews·W J Loesche
Aug 1, 1988·Infection and Immunity·D DrakeR J Doyle
Jun 1, 1980·Microbiological Reviews·S Hamada, H D Slade

❮ Previous
Next ❯

Related Concepts

Related Feeds

Allergy & Infectious Diseases (ASM)

Allergies result from the hyperreactivity of the immune system to some environmental substance and can be life-threatening. Infectious diseases are caused by organisms including bacteria, viruses, fungi and parasites. They can be transmitted different ways, such as person-to-person. Here is the latest research on allergy and infectious diseases.

Antimicrobial Resistance (ASM)

Antimicrobial resistance poses a significant threat to the continued successful use of antimicrobial agents for the treatment of bacterial infections.

Antimicrobial Resistance

Antimicrobial resistance poses a significant threat to the continued successful use of antimicrobial agents for the treatment of bacterial infections.

Allergy & Infectious Diseases

Allergies result from the hyperreactivity of the immune system to some environmental substance and can be life-threatening. Infectious diseases are caused by organisms including bacteria, viruses, fungi and parasites. They can be transmitted different ways, such as person-to-person. Here is the latest research on allergy and infectious diseases.