Virulence of Streptococcus suis type 2 for mice and pigs appeared host-specific

Veterinary Microbiology
U VechtH E Smith

Abstract

A murine model for Streptococcus suis infection in pigs was validated by inoculating groups of 5 BALB/c and 5 CF1 mice with 10(7) CFU/ml of 13 different S. suis serotype 2 strains. The pathogenicity of these strains had been established in a standardized pig model of S. suis infection using one-week-old gnotobiotic pigs. We inoculated groups of mice intraperitoneally with 4 strains that were highly virulent for pigs and belonged to the phenotype MRP+EF+, with 4 strains, that were weakly virulent for pigs and belonged to the phenotype MRP+EF+, and with 5 strains that were non-virulent for pigs and belonged to phenotype MRP-EF-. The S. suis strains that were highly virulent for pigs caused high morbidity and an intermediate mortality in mice, the S. suis strains that were weakly virulent for pigs caused high morbidity but low mortality, and the strains that were non-virulent for pigs, induced highest morbidity and mortality. These results were comparable in both breeds of mice. In contrast to the pathology of S. suis infection in pigs with specific lesions, lesions in mice were histologically often characterized as non-specific, i.e., necrotizing encephalitis and focal or diffuse hepatitis sometimes with abscesses. Irrespective o...Continue Reading

References

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Citations

Sep 6, 2000·Veterinary Microbiology·M Gottschalk, M Segura
Jun 8, 2001·Veterinary Microbiology·L O Andresen, C Tegtmeier
Mar 7, 2003·Microbial Pathogenesis·Shichun LunP J Willson
Nov 7, 2006·Applied and Environmental Microbiology·Christoph G BaumsPeter Valentin-Weigand
Mar 10, 2010·Future Microbiology·Marcelo GottschalkMariela Segura
Jan 8, 2008·Science in China. Series C, Life Sciences·ZhaoHui XiongQi Jin
Dec 12, 2012·Current Microbiology·Kaicheng WangBaoxu Huang
May 5, 2012·Journal of Medical Microbiology·Maren SeitzChristoph Georg Baums
Jan 6, 2011·FEMS Microbiology Letters·Yang WangChengping Lu
Apr 6, 2006·PLoS Medicine·Jiaqi TangGeorge F Gao
Aug 2, 2016·Comparative Immunology, Microbiology and Infectious Diseases·Lidia Gómez-GascónInmaculada Luque
Jul 19, 2016·Microbial Pathogenesis·Chengkun ZhengWeicheng Bei
Feb 6, 2007·Veterinary Microbiology·Thomas L WilsonTroy E Fuller
Aug 19, 2007·Animal Health Research Reviews·Marcelo GottschalkJiangu Xu
Oct 1, 2013·The Veterinary Record·J M Senior
Jan 15, 2000·Journal of Clinical Microbiology·M GottschalkS Quessy

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