Virulence properties of asymptomatic bacteriuria Escherichia coli

International Journal of Medical Microbiology : IJMM
Amanda N MabbettMark A Schembri

Abstract

In asymptomatic bacteriuria (ABU), bacteria colonize the urinary tract without provoking symptoms. Here, we compared the virulence properties of a collection of ABU Escherichia coli strains to cystitis and pyelonephritis strains. Specific urinary tract infection (UTI)-associated virulence genes, hemagglutination characteristics, siderophore production, hemolysis, biofilm formation, and the ability of strains to adhere to and induce cytokine responses in epithelial cells were analyzed. ABU strains were phylogenetically related to strains that cause symptomatic UTI. However, the virulence properties of the ABU strains were variable and dependent on a combination of genotypic and phenotypic factors. Most ABU strains adhered poorly to epithelial cells; however, we also identified a subgroup of strongly adherent strains that were unable to stimulate an epithelial cell IL-6 cytokine response. Poor immune activation may represent one mechanism whereby ABU E. coli evade immune detection after the establishment of bacteriuria.

Citations

Apr 22, 2011·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·N L RamosA Brauner
Jun 26, 2012·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·A GündoğduM Katouli
Jul 10, 2012·Nature Chemical Biology·Kaveri S ChaturvediJeffrey P Henderson
Jul 4, 2012·Infection and Immunity·Rebecca M VejborgViktoria Hancock
Sep 16, 2011·Journal of Clinical Microbiology·Jean-Philippe LavigneAlbert Sotto
May 15, 2013·BMC Infectious Diseases·Jonas MarschallUNKNOWN CDC Prevention Epicenters Program
May 12, 2011·PloS One·Pavel PolyakovGrégory Francius
May 8, 2010·Clinical Journal of the American Society of Nephrology : CJASN·Priscila Reina SilianoIta Pfeferman Heilberg
Jan 5, 2014·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·T L Vollmerhausen, M Katouli
Oct 19, 2011·Journal of Biomedicine & Biotechnology·Benjamin L DuellGlen C Ulett
Feb 24, 2016·Frontiers in Cellular and Infection Microbiology·Deepak S IpeGlen C Ulett
Sep 26, 2013·Journal of Microbiology, Immunology, and Infection = Wei Mian Yu Gan Ran Za Zhi·Ki Wook YunIn Seok Lim
Jan 19, 2016·Indian Journal of Medical Microbiology·Sugandha SrivastavaRicha Srivastava
Oct 18, 2015·The Urologic Clinics of North America·Matthew Ferroni, Aisha Khalali Taylor
Sep 28, 2015·The Journal of Infection·Adam P Dale, Neil Woodford
Dec 3, 2014·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Farzaneh FiroozehMohammad Zibaei
Feb 15, 2012·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·M A J BeerepootS E Geerlings
Dec 7, 2016·Nature Reviews. Urology·Carsten LeueGommert van Koeveringe
Jan 24, 2017·Journal of Feline Medicine and Surgery·Melanie L PuchotCaitlin Pohlit
Sep 23, 2014·Applied and Environmental Microbiology·Donna M EastonMark A Schembri
Jan 25, 2019·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·Mariam M YoussefNoha A Hassuna
Dec 7, 2011·Nature Reviews. Urology·Barbara W Trautner
Jan 8, 2014·Expert Review of Proteomics·Phillip Cash
Aug 22, 2020·Tierärztliche Praxis. Ausgabe K, Kleintiere/Heimtiere·Julia Harrer, Roswitha Dorsch
Apr 1, 2015·Metallomics : Integrated Biometal Science·Eun-Ik KohJeffrey P Henderson

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