PMID: 8961550Dec 1, 1996Paper

Virulence regions and virulence factors of the ovine footrot pathogen, Dichelobacter nodosus

FEMS Microbiology Letters
S J BillingtonJ I Rood

Abstract

Ovine footrot is a debilitating and highly infectious disease that is primarily caused by the Gram-negative, anaerobic bacterium Dichelobacter nodosus. The major antigens implicated in virulence are the type IV fimbriae and extracellular proteases. The fimbriae show sequence and structural similarity to other type IV fimbriae, this similarity extends to genes that are involved in fimbrial biogenesis. Several acidic and basic extracellular serine proteases are produced by both virulent and benign isolates of D. nodosus. Subtle functional differences in these proteases appear to be important in virulence. In addition, there are two chromosomal regions that have a genotypic association with virulence. The partially duplicated and rearranged vap regions appear to have arisen from the insertion of a plasmid into a tRNA gene via an integrase-mediated site-specific insertion event. The 27 kb vrl region has several genes often found on bacteriophages and has inserted into an ssrA gene that may have a regulatory role in the cell. The determination of the precise role that each of these genes and gene regions has in virulence awaits the development of methods for the genetic analysis and manipulation of D. nodosus.

References

Jan 1, 1987·Journal of Bacteriology·J S MattickJ R Egerton
Jan 1, 1993·Annual Review of Microbiology·M S Strom, S Lory
Apr 1, 1994·Journal of Bacteriology·D M RetallackD I Friedman
Sep 1, 1995·Molecular Microbiology·N Firth, R A Skurray
Mar 18, 1996·Biochemical and Biophysical Research Communications·Q B TianY Terawaki

❮ Previous
Next ❯

Citations

Mar 25, 2011·The ISME Journal·Leo A Calvo-BadoElizabeth M H Wellington
Oct 13, 2011·The Journal of Biological Chemistry·Wilson WongCorrine J Porter
Mar 9, 2010·Acta Crystallographica. Section F, Structural Biology and Crystallization Communications·Wilson WongCorrine J Porter
Feb 17, 2001·Infection and Immunity·I R Henderson, J P Nataro
Jun 22, 2006·Journal of Bacteriology·Dane ParkerJulian I Rood
Mar 4, 2008·Journal of Bacteriology·Xiaoyan HanJulian I Rood
Feb 29, 2000·Journal of Bacteriology·S M JulioM J Mahan
Feb 10, 2007·BMC Evolutionary Biology·Pradeep Reddy MarriG Brian Golding
Mar 31, 2012·Acta Veterinaria Scandinavica·Torunn RogdoTerje Fjeldaas
May 16, 1998·Proceedings of the National Academy of Sciences of the United States of America·C P ConnerM J Mahan
Dec 19, 2002·Veterinary Microbiology·Ruth M KennanJulian I Rood
Dec 2, 2000·International Journal of Medical Microbiology : IJMM·U Dobrindt, J Reidl
Aug 8, 2007·Veterinary Microbiology·Tulay I Cagatay, Jon G H Hickford
Aug 6, 2004·Molecular and Cellular Probes·S A WaniA S Buchh
Apr 21, 2006·The Veterinary Journal·S A Wani, I Samanta
Feb 17, 2017·Journal of Clinical Microbiology·Andrew S McPhersonRichard J Whittington
Nov 16, 2001·Animal Health Research Reviews·J D DubreuilM Gottschalk
Apr 13, 2021·The Veterinary Journal·Patrik ZanolariPeter Kuhnert

❮ Previous
Next ❯

Related Concepts

Related Feeds

Bacteriophage: Phage Therapy

Phage therapy uses bacterial viruses (bacteriophages) to treat bacterial infections and is widely being recognized as an alternative to antibiotics. Here is the latest research.