Virulence regulation in Staphylococcus aureus: the need for in vivo analysis of virulence factor regulation

FEMS Immunology and Medical Microbiology
Alexa A Pragman, Patrick M Schlievert

Abstract

Staphylococcus aureus is a pathogenic microorganism that is responsible for a wide variety of clinical infections. These infections can be relatively mild, but serious, life-threatening infections may result from the expression of staphylococcal virulence factors that are coordinated by virulence regulators. Much work has been done to characterize the actions of staphylococcal virulence regulators in broth culture. Recently, several laboratories showed that transcriptional analyses of virulence regulators in in vivo animal models or in human infection did not correlate with transcriptional analyses accomplished in vitro. In describing the differences between in vitro and in vivo transcription of staphylococcal virulence regulators, we hope to encourage investigators to study virulence regulators using infection models whenever possible.

References

Jul 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·A L CheungV A Fischetti
Jan 1, 1986·Molecular & General Genetics : MGG·P RecseiR P Novick
Sep 1, 1995·Infection and Immunity·A F GillaspyM S Smeltzer
Nov 1, 1994·The Journal of Clinical Investigation·A L CheungA S Bayer
Jan 1, 1996·Journal of Bacteriology·J H HeinrichsA L Cheung
Feb 28, 1998·The Journal of Biological Chemistry·Y Chien, A L Cheung
Jul 20, 1999·Molecular Microbiology·T M RechtinB K Hurlburt
May 2, 2000·Journal of Clinical Microbiology·J M Yarwood, P M Schlievert
Feb 13, 2001·Infection and Immunity·A Manna, A L Cheung
Jul 12, 2001·Infection and Immunity·K A SchmidtA L Cheung
Jan 25, 2002·Journal of Bacteriology·Jeremy M YarwoodPatrick M Schlievert
Dec 24, 2002·Infection and Immunity·Adhar C Manna, Ambrose L Cheung
Dec 24, 2002·Infection and Immunity·Jon S BlevinsMark S Smeltzer
Jan 4, 2003·Journal of Bacteriology·B Saïd-SalimB N Kreiswirth
May 7, 2003·Current Microbiology·Ana T GiraudoRosa Nagel
Jun 19, 2003·Journal of Bacteriology·Thanh T LuongChia Y Lee
Apr 3, 2004·Journal of Bacteriology·Alexa A PragmanPatrick M Schlievert

❮ Previous
Next ❯

Citations

Feb 24, 2012·Cell and Tissue Research·Joanna Koziel, Jan Potempa
Sep 17, 2005·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·J MaierH Linde
Jan 27, 2007·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·U ReischlH Linde
May 2, 2008·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·G JacobssonR Andersson
Oct 18, 2005·Current Infectious Disease Reports·Tristan FerryJerome Etienne
Nov 26, 2009·Avian Pathology : Journal of the W.V.P.A·Mostafa NematiFreddy Haesebrouck
Apr 19, 2008·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Patrick M SchlievertDonald Y M Leung
Sep 11, 2008·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Costi D Sifri
Dec 31, 2005·Journal of Bacteriology·Jennifer A Loughman, Michael Caparon
Jul 5, 2013·Clinical Microbiology Reviews·Adam R SpauldingPatrick M Schlievert
Jun 7, 2005·Expert Opinion on Therapeutic Targets·John F Barrett
Nov 14, 2014·Genome Medicine·Frank HansesJean C Lee
Oct 4, 2015·Microbiology·Elizabeth A MuellerPatrick M Schlievert
Apr 24, 2010·Veterinary Microbiology·Renata PiccininiAlfonso Zecconi
May 20, 2014·Immunologic Research·Christopher S StachPatrick M Schlievert
Apr 26, 2007·Chembiochem : a European Journal of Chemical Biology·Elizabeth A George, Tom W Muir
Sep 27, 2012·Microbiological Research·Nicole M Mackey-Lawrence, Kimberly K Jefferson
Jul 12, 2016·International Journal of Food Microbiology·Justyna SchubertJacek Bania
Aug 21, 2013·Antimicrobial Agents and Chemotherapy·Patrick M SchlievertJohn R Kirby
Jan 20, 2018·Emerging Infectious Diseases·Hema SharmaShiranee Sriskandan
Sep 3, 2019·Current Pharmaceutical Biotechnology·Fazlurrahman KhanYoung-Mog Kim
Jul 17, 2020·Frontiers in Microbiology·Yongpeng ShangDi Qu
Jan 8, 2021·Frontiers in Microbiology·Priscila Dauros-SingorenkoSimon Swift

❮ Previous
Next ❯

Related Concepts

Related Feeds

CRISPR & Staphylococcus

CRISPR-Cas system enables the editing of genes to create or correct mutations. Staphylococci are associated with life-threatening infections in hospitals, as well as the community. Here is the latest research on how CRISPR-Cas system can be used for treatment of Staphylococcal infections.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis