Abstract
Escherichia coli isolated from asymptomatic bacteriuria (ABU) correlated genotypically and phenotypically with cystitis isolates may help in distinguishing urovirulence determinants from 'fitness factors', latter necessary only for survival of E. coli in urinary tract; for gaining insight into the pathogenesis of urinary tract infection. In this cross-sectional study, we compared genotypic (phylogroups and 15 putative virulence genes), and phenotypic profiles of ABU E. coli strains with our previously genotyped collection of cystitis isolates. Virulence score was calculated for each isolate as a number of virulence genes detected. Significant differences were observed in the proportion of four phylogenetic groups (P=0.009) amongst cystitis and ABU isolates. Average virulence score was higher for ABU isolates (6.6) than cystitis strains (4.2); and hlyA (P=0.001), cytotoxic necrotising factor 1 (P=0.00), fyuA (P=0.00), ibeA (P=0.00), kpsMII (P=0.01), and malX/pathogenicity-associated island (P=0.01) were more frequently present in ABU strains. The expression of adhesins, haemolysin, aerobactin, and capsule synthesis gene were similar in two groups suggesting their role as fitness factors. ABU isolates were better biofilm producer...Continue Reading
References
Feb 1, 1978·The Journal of Pediatrics·U LindbergU Jodal
May 1, 1975·Acta paediatrica Scandinavica·U LindbergS Olling
Jan 1, 1991·Clinical Microbiology Reviews·J R Johnson
May 21, 1999·Science·J W CostertonE P Greenberg
Dec 23, 1999·The Journal of Infectious Diseases·J R Johnson, A L Stell
Sep 30, 2000·Applied and Environmental Microbiology·O ClermontE Bingen
Oct 6, 2000·The New England Journal of Medicine·T M HootonW E Stamm
Jul 13, 2002·The American Journal of Medicine·Allan Ronald
Nov 29, 2005·Comparative Immunology, Microbiology and Infectious Diseases·G RamaS Sharma
Dec 15, 2006·FEMS Microbiology Letters·Viktoria HancockPer Klemm
May 18, 2007·Journal of Microbiological Methods·S Pérez-MirandaF J Fernández
Nov 28, 2007·Infection and Immunity·Jaroslaw ZdziarskiUlrich Dobrindt
Mar 5, 2008·Molecular Genetics and Genomics : MGG·Viktoria HancockPer Klemm
Aug 19, 2008·International Journal of Medical Microbiology : IJMM·Amanda N MabbettMark A Schembri
Oct 25, 2008·Revista Do Instituto De Medicina Tropical De São Paulo·Monique Ribeiro TibaDomingos da Silva Leite
Jan 12, 2011·Infection and Immunity·Erin C GarciaHarry L T Mobley
Apr 6, 2011·PloS One·Savita JadhavNiyaz Ahmed
Jun 17, 2011·BMC Genomics·Rebecca Munk VejborgPer Klemm
Nov 23, 2011·Infection and Immunity·Ellaine SalvadorUlrich Dobrindt
Dec 23, 2011·Journal of Clinical Microbiology·Sam AbrahamMark A Schembri
Jun 6, 2012·Indian Journal of Medical Microbiology·J AgarwalM Singh
Jan 9, 2013·Transactions of the Royal Society of Tropical Medicine and Hygiene·Jyotsna AgarwalRicha Srivastava
Citations
Mar 6, 2019·Folia Microbiologica·Arunita Ghosh, Mandira Mukherjee
Aug 17, 2019·Annals of African Medicine·Unnimaya PullanhiAnil Kumar
Jul 1, 2021·International Microbiology : the Official Journal of the Spanish Society for Microbiology·Arunita GhoshMandira Mukherjee