PMID: 7019417Feb 1, 1981Paper

Virulent and avirulent strains of Babesia bovis: The relationship between parasite protease content and pathophysiological effect on the strain

The Journal of protozoology
I G WrightD F Mahoney

Abstract

A virulent strain of Babesia bovis ("L" strain) was rendered avirulent by irradiation with 35 krads with a gamma source. Another virulent strain of B. bovis ("C" strain) was made avirulent by rapid blood passage through 12 splenectomised calves. Both the parent virulent and their respective avirulent strains were injected into susceptible cattle. A nonfatal disease was observed in those intact cattle that had received avirulent parasites; however, a fatal disease was produced in those animals that had received virulent parasites and in splenectomised calves that had received avirulent parasites. Blood kinin levels rose and plasma kininogen levels fell significantly in those animals infected with both virulent strains. Nonsignificant changes occurred with these parameters in animals infected with avirulent parasites. Preparations of disrupted parasites were obtained from the four parasite populations. Both virulent strains contained high levels of protease. The avirulent forms contained insignificant amounts. As parasite doubling times and maximum parasitaemias were the same for all four parasite populations, we conclude that these enzymes are not obligatory for parasite multiplication in the vertebrate host. Their role in produ...Continue Reading

References

Oct 1, 1977·Journal of Comparative Pathology·I G Wright, J D Kerr
Jan 1, 1977·Advances in Experimental Medicine and Biology·L L Callow
Jun 1, 1973·Annals of Tropical Medicine and Parasitology·W H Richards, S G Williams
Jun 21, 1974·Zeitschrift Für Parasitenkunde·I G Wright, D F Mahoney
Sep 1, 1966·Annals of Tropical Medicine and Parasitology·A Tella, B G Maegraith
Apr 1, 1967·Experimental Parasitology·D F Mahoney
Jan 1, 1980·Zeitschrift Für Parasitenkunde·D F MahoneyB V Goodger

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Citations

Jan 1, 1983·Zeitschrift Für Parasitenkunde·I G WrightD J Waltisbuhl
Feb 1, 1987·International Journal for Parasitology·G H Coombs
Jan 1, 1989·Transactions of the Royal Society of Tropical Medicine and Hygiene·I G WrightD J Waltisbuhl
Aug 1, 1988·Parasitology Today·I G WrightI A Clark
Jan 1, 1991·Veterinary Parasitology·M A HabelaS Hernández
Oct 22, 1998·Zentralblatt für Veterinärmedizin. Reihe B. Journal of veterinary medicine. Series B·I YeruhamE Bogin
Nov 1, 1986·The Journal of protozoology·S D RodriguezC A Carson
Sep 1, 1994·Australian Veterinary Journal·D F Mahoney
Oct 1, 1983·Infection and Immunity·S D RodriguezC A Carson

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