PMID: 11900836Mar 20, 2002Paper

Virulent influenza A viruses induce apoptosis in chickens

Virus Research
Toshihiro ItoYoshihiro Kawaoka

Abstract

Virulent avian influenza A viruses produce lethal disease in chickens. Since cell death can be caused by either necrosis or apoptosis, we investigated the types of cell death that occur in natural hosts, chickens, infected with virulent avian viruses. Using biochemical methods, we demonstrate that virulent avian influenza viruses induce apoptosis of vascular endothelial cells in liver, kidney, and brain. Viral antigens were also detected in these organs, suggesting that viral replication induces apoptosis in infected chickens. These results indicate that apoptosis does occur in virulent avian influenza virus infection in a natural host, and may contribute to the lethality of the virus.

References

Nov 1, 1992·The Journal of Cell Biology·Y GavrieliS A Ben-Sasson
May 1, 1991·The Journal of Clinical Investigation·C TeraiD A Carson
Sep 1, 1981·Virology·R G WebsterG Petursson
Nov 1, 1995·The Journal of General Virology·I MoriY Kimura
Jul 1, 1994·The Journal of General Virology·A C Vasconcelos, K M Lam
Feb 1, 1994·Trends in Microbiology·H D Klenk, W Garten
Jun 1, 1994·Journal of Virology·V S HinshawD Evans
Apr 1, 1993·Genes & Development·M Debbas, E White
Apr 1, 1993·Journal of Virology·N E CrookL K Miller
Mar 1, 1996·Journal of Virology·J LewisJ M Hardwick
Sep 3, 1996·Proceedings of the National Academy of Sciences of the United States of America·R Leopardi, B Roizman
Feb 1, 1996·Journal of Comparative Pathology·Y KobayashiC Itakura
Dec 1, 1996·Journal of Virology·S Schultz-Cherry, V S Hinshaw
Mar 1, 1997·The Journal of Veterinary Medical Science·F D SilvanoT Umemura
Jul 22, 1997·Proceedings of the National Academy of Sciences of the United States of America·R LeopardiB Roizman
Jan 1, 1997·British Medical Bulletin·L S YoungA G Eliopoulos
Apr 8, 1998·Current Opinion in Genetics & Development·J TschoppE Meinl
Feb 6, 1999·The Journal of General Virology·S J MorrisC Sweet
May 25, 1999·Microbiology and Immunology·T TakizawaY Nakanishi
Aug 6, 2000·Cell and Tissue Research·C Stadelmann, H Lassmann
Jun 1, 1996·Avian Pathology : Journal of the W.V.P.A·Y KobayashiC Itakura

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Citations

Aug 6, 2011·Journal of Molecular Cell Biology·Ning YangChengyu Jiang
Jul 5, 2005·Journal of Virology·Elizabeth TurpinStacey Schultz-Cherry
Mar 5, 2011·BMC Public Health·Benjamin P Holder, Catherine A A Beauchemin
Oct 10, 2013·BioMed Research International·Shahla ShahsavandiAshraf Mohammadi
Aug 5, 2010·Journal of Molecular Histology·Ralph ThoméNilo Bazzoli
Jul 12, 2008·Veterinary Immunology and Immunopathology·Luciana SarmentoMary Pantin-Jackwood
Aug 19, 2007·Research in Veterinary Science·Wanpo ZhangDingren Bi
Feb 14, 2006·Cellular Microbiology·Stephan LudwigThorsten Wolff
Dec 19, 2014·Frontiers in Microbiology·Kirsty R ShortThijs Kuiken
Mar 9, 2017·International Reviews of Immunology·Anamika MishraAshwin Ashok Raut
Aug 24, 2017·International Journal of Environmental Research and Public Health·Alberto Romão SinequeFilomena Rosa Dos Anjos
Jun 2, 2004·Journal of Medical Virology·Huimin YanGeorge F Gao
Apr 23, 2008·Journal of Medical Virology·Makoto SumikoshiMitsuaki Hosoya

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Related Concepts

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Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis