Virus and Mycoplasma pneumoniae prevalence in a selected pediatric population with acute asthma exacerbation

The Journal of Asthma : Official Journal of the Association for the Care of Asthma
Elida Duenas MezaMaría Del Pilar Delgado

Abstract

To determine the prevalence of viral and atypical bacteria Mycoplasma pneumoniae infection in children experiencing asthma exacerbation and compare positive and negative subjects with regard to exacerbation severity, need for hospitalization, and treatment. One hundred sixty-nine asthmatic children aged 2-15 years old who were admitted to emergency rooms in Bogota, Colombia for acute asthma exacerbation were interviewed. Nasopharyngeal aspirates were taken for DNA and RNA extraction. M. pneumoniae and virus were detected by PCR using specific primers. The prevalence of M. pneumoniae and viral infection in the study population was 12.4% and 83.7%, respectively. All subjects positive for M. pneumoniae were also positive for viral infection. Rhinovirus was the most frequently detected viral agent. No significant differences in severity of asthma exacerbations or in need for hospitalization between the virus or M. pneumoniae positive and negative groups were observed. A significantly lower percentage of M. pneumoniae positive subjects had used inhaled steroids over the six months prior to asthma exacerbation compared to M. pneumoniae negative subjects (38.1% vs. 68.2%), suggesting that inhaled corticosteroids may have a protective ...Continue Reading

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Citations

Oct 7, 2016·American Journal of Respiratory and Critical Care Medicine·Sandeep PuranikJuan C Celedón
Jun 22, 2017·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Pamela R WoodEdward G Brooks
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Jun 6, 2018·Pediatrics·Joanna MerckxUNKNOWN Pediatric Emergency Research Canada (PERC) DOORWAY team

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