Virus antibody survey in different European populations indicates risk association between coxsackievirus B1 and type 1 diabetes

Sami OikarinenVirDiab Study Group


Enteroviruses (EVs) have been connected to type 1 diabetes in various studies. The current study evaluates the association between specific EV subtypes and type 1 diabetes by measuring type-specific antibodies against the group B coxsackieviruses (CVBs), which have been linked to diabetes in previous surveys. Altogether, 249 children with newly diagnosed type 1 diabetes and 249 control children matched according to sampling time, sex, age, and country were recruited in Finland, Sweden, England, France, and Greece between 2001 and 2005 (mean age 9 years; 55% male). Antibodies against CVB1 were more frequent among diabetic children than among control children (odds ratio 1.7 [95% CI 1.0-2.9]), whereas other CVB types did not differ between the groups. CVB1-associated risk was not related to HLA genotype, age, or sex. Finnish children had a lower frequency of CVB antibodies than children in other countries. The results support previous studies that suggested an association between CVBs and type 1 diabetes, highlighting the possible role of CVB1 as a diabetogenic virus type.


May 24, 1979·The New England Journal of Medicine·J W YoonA L Notkins
Jun 1, 1968·The Journal of Clinical Investigation·G S SalibaG G Jackson
Sep 13, 1969·British Medical Journal·D R GambleK W Taylor
May 25, 2004·Diabetic Medicine : a Journal of the British Diabetic Association·J GreenR Newton
Mar 16, 2007·Proceedings of the National Academy of Sciences of the United States of America·Francesco DottaPiero Marchetti
Jul 23, 2009·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Mary E WikswoM Steven Oberste
Oct 15, 2010·Diabetes·Sami OikarinenHeikki Hyöty
Aug 4, 2011·Hormone Research in Pædiatrics·Mikael Knip
Feb 9, 2012·Cold Spring Harbor Perspectives in Medicine·Ken T CoppietersMatthias von Herrath
Jan 1, 2012·The Review of Diabetic Studies : RDS·Noora NurminenHeikki Hyöty

❮ Previous
Next ❯


Jul 31, 2014·Diabetologia·Darius A Schneider, Matthias G von Herrath
Jan 13, 2015·Journal of Pathogens·Jana PrecechtelovaShubhada Bopegamage
Sep 2, 2014·Trends in Endocrinology and Metabolism : TEM·Noel G Morgan, Sarah J Richardson
Mar 13, 2014·International Reviews of Immunology·Anita Kondrashova, Heikki Hyöty
Jun 27, 2014·Expert Review of Vaccines·Heikki Hyöty, Mikael Knip
Dec 9, 2014·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Juha Grönholm, Michael J Lenardo
Aug 6, 2015·Archives of Virology·Ichrak AbdelkhalekDorra Rezig
Mar 13, 2014·Journal of Medical Virology·Sanna HämäläinenHeikki Hyöty
Mar 30, 2016·Nature Reviews. Endocrinology·Anne Op de Beeck, Decio L Eizirik
Aug 19, 2015·Current Diabetes Reports·Antje PetzoldKlaus-Peter Knoch
Jun 30, 2015·Scandinavian Journal of Immunology·M T HeinonenR Lahesmaa
Mar 12, 2015·Proteomics·Xiaofang BianJoshua LaBaer
Nov 29, 2014·Reviews in Medical Virology·Kristen M DrescherSteven Tracy
Jul 26, 2015·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Jutta E LaihoHeikki Hyöty
Sep 9, 2015·Mediators of Inflammation·Marta NovotnaJana Duskova
Apr 20, 2016·Scientific Reports·Giuseppe MaccariAntonio Toniolo
Apr 25, 2015·Diabetes·Teresa Rodriguez-Calvo, Matthias G von Herrath
Mar 26, 2015·European Journal of Endocrinology·Ben BoursiYu-Xiao Yang
Apr 18, 2015·BioMed Research International·Johanna BodinUnni Cecilie Nygaard
Jun 9, 2015·PloS One·Pei-Yu ChuKazushi Motomura
Jun 9, 2016·Journal of Clinical Medicine·Navena NavaneetharajaSimon R Carding
Jul 15, 2016·Pediatric Diabetes·Heikki Hyöty
Jul 15, 2016·Pediatric Diabetes·Michael J Haller, Desmond A Schatz
Sep 25, 2016·Current Diabetes Reports·Chris Fraker, Allison L Bayer
Jul 29, 2015·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Teresa Rodriguez-CalvoMatthias G von Herrath
Jan 11, 2018·Medical Principles and Practice : International Journal of the Kuwait University, Health Science Centre·Adel Abdel-MoneimRehab G Khalil
Jan 10, 2018·Frontiers in Immunology·Matthew ClarkRoland M Tisch
May 31, 2018·Current Opinion in Rheumatology·Oded Shamriz, Yehuda Shoenfeld
Oct 12, 2018·Clinical and Experimental Immunology·T Rodriguez-Calvo
Nov 20, 2018·Expert Review of Vaccines·Heikki HyötyMikael Knip
Mar 19, 2014·Clinical and Experimental Immunology·J L DunneM A Atkinson
Nov 11, 2019·Diabetic Medicine : a Journal of the British Diabetic Association·A B Sioofy-KhojineH Hyöty
Dec 4, 2019·Nature Medicine·Kendra VehikUNKNOWN TEDDY Study Group
Jun 13, 2020·Journal of Medical Virology·Ilaria SciandraOmbretta Turriziani
Mar 24, 2016·Journal of Pediatric Endocrinology & Metabolism : JPEM·Engelina A J M SpaansNanne Kleefstra

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diabetes & Tolerance

Patients with type I diabetes lack insulin-producing beta cells due to the loss of immunological tolerance and autoimmune disease. Discover the latest research on targeting tolerance to prevent diabetes.

American Diabetes Association Journals

Discover the latest diabetes research published by the journals from the American Diabetes Association.