PMID: 9445038Jan 28, 1998Paper

Virus attenuation after deletion of the cytomegalovirus Fc receptor gene is not due to antibody control

Journal of Virology
I Crnkovic-MertensUlrich H Koszinowski

Abstract

The murine cytomegalovirus (MCMV) fcr-1 gene codes for a glycoprotein located at the surface of infected cells which strongly binds the Fc fragment of murine immunoglobulin G. To determine the biological significance of the fcr-1 gene during viral infection, we constructed MCMV fcr-1 deletion mutants and revertants. The fcr-1 gene was disrupted by insertion of the Escherichia coli lacZ gene. In another mutant, the marker gene was also deleted, by recombinase cre. As expected for its hypothetical role in immunoevasion, the infection of mice with fcr-1 deletion mutants resulted in significantly restricted replication in comparison with wild-type MCMV and revertant virus. In mutant mice lacking antibodies, however, the fcr-1 deletion mutants also replicated poorly. This demonstrated that the cell surface-expressed viral glycoprotein with FcR activity strongly modulates the virus-host interaction but that this biological function is not caused by the immunoglobulin binding property.

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Citations

Apr 25, 2008·Current Protocols in Immunology·W BruneU H Koszinowski
Aug 10, 2016·The Journal of Experimental Medicine·Tihana Lenac RovisStipan Jonjic
Nov 2, 2019·Nature Reviews. Immunology·Richard BerryJamie Rossjohn
Jan 21, 2003·The Journal of General Virology·Herman W FavoreelMaurice B Pensaert
Jul 13, 2006·The Journal of Experimental Medicine·Tihana LenacStipan Jonjic
Jul 28, 1999·FEMS Microbiology Reviews·C Sweet
Sep 21, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·D G KavanaghA B Hill
May 22, 2002·Nature Immunology·Astrid KrmpotićStipan Jonjić
Jul 25, 2000·Journal of Virology·C VinkC A Bruggeman
Jan 25, 2008·Journal of Virology·Elizabeth R SpraguePamela J Bjorkman
Dec 5, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Justine D MinternHidde L Ploegh
Feb 9, 2008·Medical Microbiology and Immunology·Tihana LenacStipan Jonjić
Oct 8, 2014·Seminars in Immunopathology·Eugenia Corrales-AguilarHartmut Hengel
Apr 8, 2011·Journal of Virology·Paul LacazePeter Ghazal
May 10, 2000·Proceedings of the National Academy of Sciences of the United States of America·D A LeibH W Virgin
Apr 7, 2017·European Journal of Immunology·Domènec FarréAna Angulo
Apr 15, 2004·Immunology Letters·Muriel ViauMoncef Zouali
Feb 17, 2007·Journal of Virological Methods·Alice A BickerstaffCharles H Cook

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