Virus-derived anti-inflammatory proteins: potential therapeutics for cancer

Trends in Molecular Medicine
Donghang ZhengAlexandra Lucas

Abstract

Inflammatory responses now have a defined central role in cancer cell growth, invasion, and metastases. Anti-inflammatory proteins from viruses target key stages in immune response pathways and have potential as novel therapeutics for cancer, including highly potent virus-derived inhibitors of protease, chemokine, cytokine, and apoptotic cascades that have been identified. Serine proteases, in addition to their conventional roles in thrombosis, thrombolysis, and apoptotic pathways, are essential regulators of inflammation and are associated with developing cancers. Chemokines drive other inflammatory response pathways with central roles in cell invasion and activation as well as establishing the microenvironment of tumors, modulating immune cell infiltration, cancer cell proliferation, metastasis, and angiogenesis. This review focuses on the mechanisms of action and potential for application of viral immunomodulatory proteins as anticancer therapeutics.

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Citations

Jul 16, 2013·Virus Genes·George F RohrmannDavid A Theilmann
Dec 29, 2016·Nature Reviews. Immunology·Jan Felix, Savvas N Savvides
Jan 21, 2017·PloS One·Nerea MatamalaBeatriz Martinez-Delgado
Apr 11, 2018·PeerJ·Jialing BaoZeyang Zhou
May 22, 2019·Journal of Immunology Research·Aneesh ThakurGregers Jungersen

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