Virus detection and cytokine profile in relation to age among acute exacerbations of childhood asthma

Allergology International : Official Journal of the Japanese Society of Allergology
Masahiko KatoHiroyuki Mochizuki

Abstract

Little information is available regarding eosinophil activation and cytokine profiles in relation to age in virus-induced bronchial asthma. We therefore explored the association between age, respiratory viruses, serum eosinophil cationic protein (ECP), and cytokines/chemokines in acute exacerbations of childhood asthma. We investigated viruses in nasal secretions from 88 patients with acute exacerbation of childhood asthma by using antigen detection kits and/or RT-PCR, followed by direct DNA sequencing analysis. We also measured peripheral eosinophil counts, and the serum levels of ECP and 27 types of cytokines/chemokines in 71 virus-induced acute asthma cases and 13 controls. Viruses were detected in 71(80.7%) of the 88 samples. The three major viruses detected were rhinoviruses, RS viruses, and enteroviruses; enteroviruses were found to be dominant in patients aged ≥3 years. There was no change in the levels of rhinoviruses and RS viruses between the two age groups, defined as children aged <3 years and children aged ≥3 years. Serum concentrations of ECP, IL-5, and IP-10 were significantly elevated in virus-induced acute asthma cases compared with controls. Serum ECP values were significantly higher in patients with virus-ind...Continue Reading

References

May 13, 1995·BMJ : British Medical Journal·S L JohnstonD A Tyrrell
Oct 16, 1993·BMJ : British Medical Journal·K G NicholsonD C Ireland
May 12, 2000·American Journal of Respiratory and Critical Care Medicine·N SigursB Kjellman
Dec 9, 2000·The Journal of Biological Chemistry·P LoetscherI Clark-Lewis
Sep 14, 2001·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·J M Smart, A S Kemp
Nov 27, 2001·Inflammatory Bowel Diseases·Y H YuanA A te Velde
Aug 19, 2004·The Journal of Allergy and Clinical Immunology·Peter W HeymannRachel Chamberlain
Nov 2, 2004·American Journal of Respiratory and Critical Care Medicine·Nele SigursBengt Kjellman
Nov 13, 2004·The Journal of Allergy and Clinical Immunology·Robert F Lemanske
Sep 15, 2005·The Journal of Allergy and Clinical Immunology·Robert F LemanskeJames E Gern
Apr 19, 2006·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Norio KawamotoNaomi Kondo
Jul 14, 2007·The Journal of Allergy and Clinical Immunology·Peter A B WarkDonna E Davies
Sep 19, 2007·Journal of Viral Hepatitis·M ZeremskiA H Talal
Jan 2, 2008·The European Respiratory Journal·E D BatemanH J Zar
Jun 21, 2008·American Journal of Respiratory and Critical Care Medicine·Daniel J JacksonRobert F Lemanske
Oct 20, 2009·Chest·Jennifer K QuintJadwiga A Wedzicha
Apr 23, 2010·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Masahiko KatoHirokazu Kimura
Jun 22, 2010·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Michael F E RoeDiarmuid R O'Donnell

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Citations

Jun 12, 2016·Cytokine·Shirin FarjadianSaeed Hosseini Teshnizi
Mar 27, 2018·Expert Review of Respiratory Medicine·Job J M H van BragtAnke H Maitland-van der Zee
Nov 8, 2018·Pediatrics International : Official Journal of the Japan Pediatric Society·Mitsuaki KimuraTakaaki Meguro
Aug 27, 2019·Pediatrics International : Official Journal of the Japan Pediatric Society·Yoshifumi MurayamaHiroyuki Mochizuki
Aug 23, 2020·Journal of Clinical Medicine·Yosuke FukudaHironori Sagara

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Methods Mentioned

BETA
PCR
electrophoresis

Software Mentioned

SPSS
GraphPad Prism
Bio
Plex
GraphPad

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