PMID: 18214191DOI: 10.3201/eid1307.070068Jan 25, 2008Paper
Virus detection and monitoring of viral load in Crimean-Congo hemorrhagic fever virus patients.
Emerging Infectious Diseases
Roman WölfelChristian Drosten
Abstract
We developed a real-time reverse transcription--PCR that detected 1,164 copies/mL of Crimean-Congo hemorrhagic fever virus per milliliter of serum at 95% probability (probit analysis) and was 100% concordant with nested PCR on 63 samples from 31 patients with confirmed infection. Infected patients who died appeared to have higher viral loads; low viral loads correlated with IgG detection.
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PCR
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