Virus-encoded serine proteinase inhibitor SERP-1 inhibits atherosclerotic plaque development after balloon angioplasty

Circulation
Alexandra LucasG McFadden

Abstract

Recurrent atherosclerotic plaque growth, restenosis, is a significant clinical problem after interventional procedures. Initiation of restenosis involves activation of inflammatory and thrombotic cascades, which are regulated by serine proteinase enzymes and inhibitors. We have investigated the use of a viral serine proteinase inhibitor, SERP-1, to reduce plaque development after primary balloon angioplasty. This is the first experimental report of the use of a viral anti-inflammatory protein for the prevention of atherosclerosis. Seventy-four cholesterol-fed rabbits were treated with either local or systemic infusions of SERP-1 protein (or control solutions) after balloon-mediated injury. Sites of SERP-1 infusion in rabbits had dramatically reduced plaque compared with control infusions at the 4-week follow-up. At low-dose infusions (30 to 300 pg), only the primary infusion site had a demonstrable decrease in plaque, whereas at higher-dose infusions (> 3000 pg), a generalized reduction in plaque development was detected. An associated decrease in mononuclear cell infiltration of the arterial wall was detected after SERP-1 infusion within the first 24 hours. Infusion of an active-site mutant of SERP-1 (P1-P1', ala-ala) lacking ...Continue Reading

References

Dec 4, 1992·Annals of the New York Academy of Sciences·C L Jackson, M A Reidy
Nov 11, 1992·Journal of the American College of Cardiology·R S SchwartzE J Topol
Jan 30, 1992·The New England Journal of Medicine·V FusterJ H Chesebro
Feb 1, 1992·Journal of the American College of Cardiology·S G Ellis, D W Muller
Mar 1, 1991·Microbiological Reviews·R M Buller, G J Palumbo
Feb 1, 1990·Journal of the American College of Cardiology·H Wolinsky, S N Thung
Aug 10, 1973·Science·C G FabricantJ H Gillespie
Aug 1, 1995·Journal of Leukocyte Biology·D C Altieri
Mar 1, 1994·Catheterization and Cardiovascular Diagnosis·Q RasheedJ M Hodgson
May 19, 1994·The New England Journal of Medicine·G H Gibbons, V J Dzau
Dec 1, 1993·The British Journal of Surgery·A W BradburyC V Ruckley
Feb 1, 1994·Clinical and Experimental Immunology·K D ForsythI Beckman
Jan 1, 1996·Annual Review of Immunology·M K Spriggs
Jan 5, 1996·Atherosclerosis·A LucasM Radosavljevic

❮ Previous
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Citations

Sep 26, 2002·Virus Research·Peter C Turner, Richard W Moyer
Jan 13, 1998·Journal of the American College of Cardiology·R KornowskiM B Leon
Nov 15, 2000·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·A LucasL Miller
Jan 5, 2007·Immunology and Cell Biology·Gunasegaran Karupiah, Geeta Chaudhri
Jan 18, 2007·Immunology and Cell Biology·Marianne M StanfordGeeta Chaudhri
Jun 2, 1998·Kidney International·P Carmeliet, D Collen
Jun 26, 2002·Viral Immunology·Peter Kerr, Grant McFadden
Mar 30, 2006·Transplantation·Eric L R BédardRobert Zhong
Jul 10, 1999·Immunological Reviews·P NashG McFadden
May 14, 2003·Journal of Virology·J B Johnston, Grant McFadden
Jan 25, 2003·Annual Review of Immunology·Bruce T SeetGrant McFadden
Jun 7, 2000·The Journal of Clinical Investigation·P M Murphy
Jan 21, 2012·Journal of Dental Research·L KesavaluA Progulske-Fox
May 23, 2014·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Ernest BrahnColin Macaulay
May 28, 2014·European Heart Journal·Paul M Ridker, Thomas F Lüscher
Nov 25, 2000·Metabolism: Clinical and Experimental·M W HattonA Lucas
Dec 24, 2005·Expert Opinion on Biological Therapy·Caroline Johnson-LégerAmanda E I Proudfoot
Dec 1, 2001·Expert Opinion on Biological Therapy·S A Smith, G J Kotwal
Aug 29, 2012·The Canadian Journal of Cardiology·Valérie DuchatelleJean-Claude Tardif
Jul 20, 2007·Cardiovascular Pathology : the Official Journal of the Society for Cardiovascular Pathology·Mary RichardsonAlexandra Lucas
Aug 22, 2006·Trends in Immunology·Padraic G Fallon, Antonio Alcami
Apr 29, 2015·Atherosclerosis·Razi KhanPhilippe L L'Allier
Aug 12, 1999·Journal of the American Geriatrics Society·D HamermanD Silver
Nov 24, 1999·Virology·C CameronG McFadden
Dec 9, 2016·Expert Opinion on Emerging Drugs·Marie-Jeanne Bertrand, Jean-Claude Tardif
Aug 8, 1998·The Journal of Biological Chemistry·P NashG McFadden
Dec 5, 2008·Journal of Leukocyte Biology·Kasinath ViswanathanAlexandra R Lucas

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