PMID: 6167549Oct 1, 1980Paper

Virus-immune cytotoxic T cells recognize structural differences between serologically indistinguishable HLA-A2 molecules

Human Immunology
W E BiddisonS Shaw

Abstract

The self-specificity of human influenza virus-immune cytotoxic T cells has been analyzed in order to identify the relationship between the self-determinants which they recognize and the serologically defined HLA-A and -B antigenic determinants. Virus-immune T cells were generated in vitro by culture of normal adult peripheral blood lymphocytes with A/HK influenza virus. Virus-immune effectors from HLA-A2 positive donors were tested on panels of virus-infected target cells from donors who were either HLA-mismatched or matched only for the HLA-A2 specificity. Virus-immune T cells from 11/11 A2-positive donors lysed all A2-matched virus-infected target cells (and no HLA-mismatched targets), except that each of these effector cell populations consistently failed to lyse the virus-infected target cells from one A2-positive donor (designated M7). Although the A2 antigen of donor M7 could also be distinguished from the A2 antigen of other donors by alloimmune cytotoxic T cells, no differences in the A2 antigen of donor M7 could be defined by extensive serological analyses. Results of isoelectric focusing of A2 molecules from three individuals plus M7 demonstrated that the M7 A2 heavy-polypeptide chain is structurally distinct. These r...Continue Reading

References

Sep 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·H T OrrJ L Strominger
Dec 1, 1979·Cell·M S KrangelJ L Strominger
Aug 1, 1977·The Journal of Experimental Medicine·D A Thorley-LawsonJ L Strominger
Apr 7, 1977·Nature·E GoulmyJ J van Rood
Mar 1, 1979·The Journal of Experimental Medicine·S Shaw, W E Biddison
Mar 1, 1978·Analytical Biochemistry·B S SingerL Gold
Mar 1, 1976·Proceedings of the National Academy of Sciences of the United States of America·C TerhorstJ L Strominger
Jan 1, 1972·Proceedings of the National Academy of Sciences of the United States of America·M J TurnerA R Sanderson
Oct 1, 1974·Proceedings of the National Academy of Sciences of the United States of America·P ParhamJ L Strominger
May 7, 1974·Biochemical and Biophysical Research Communications·S C Kuo, J O Lampen
Nov 1, 1971·Analytical Biochemistry·D N Talbot, D A Yphantis
Jan 1, 1980·The Journal of Experimental Medicine·D A Shackelford, J L Strominger
May 1, 1980·Springer Seminars in Immunopathology·A J McMichael

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Citations

Jan 1, 1985·Immunogenetics·S Y YangE J Yunis
Jan 1, 1983·Immunogenetics·J J van der PoelH L Ploegh
Jan 1, 1988·Immunogenetics·R CastañoJ A López de Castro
Aug 1, 1982·Human Immunology·F C GrumetE G Engleman
Aug 1, 1982·Human Immunology·F H ClaasJ J van Rood
Feb 1, 1983·Human Immunology·H H MöldersH L Ploegh
Apr 1, 1984·Human Immunology·M H BreuningP Iványi
Oct 1, 1984·Human Immunology·A W HahnH L Ploegh
Jul 1, 1986·Human Immunology·J J van der PoelJ J van Rood
Sep 1, 1987·Human Immunology·B D ClarkP I Terasaki
Feb 1, 1990·Human Immunology·L ZhangF H Claas
Mar 1, 1992·Human Immunology·M A Fernandez-ViñaP Stastny
Mar 1, 1992·Human Immunology·K T Hogan, S L Brown
Dec 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·D PiousJ L Strominger
Nov 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·M A VegaJ A López de Castro
Dec 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·A J McMichaelJ L Strominger
Jan 1, 1984·Immunogenetics·E GoulmyJ J van Rood
Jan 1, 1983·Immunogenetics·V H Engelhard, C Benjamin
Jan 1, 1984·Immunogenetics·E GomardJ P Lévy
Mar 23, 2012·PloS One·Peter HorbyJ Kenneth Baillie
Jul 1, 1985·Immunological Reviews·J A Lopez de CastroJ L Strominger

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