Virus-induced autoimmune disease

Current Opinion in Immunology
M G von Herrath, M B Oldstone

Abstract

The breaking of tolerance or unresponsiveness to self-antigens, involving the activation of autoreactive lymphocytes, is a critical event leading to autoimmune diseases. The precise mechanisms by which this can occur are mostly unknown. Viruses have been implicated in this process, among other etiological factors, such as genetic predisposition and cytokine activity. Several ways have been proposed by which a viral infection might break tolerance to self and trigger an autoreactive cascade that ultimately leads to the destruction of a specific cell type or an entire organ. The process termed "molecular mimicry' and the use of transgenic models in which viral and host genes can be manipulated to analyze their effects in causing autoimmunity have been particular focuses for research. For example, there is a transgenic murine model of virus-induced autoimmune disease, in which a known viral gene is selectively expressed as a self-antigen in beta cells of the pancreas. In these mice, insulin-dependent diabetes develops after either a viral infection, the release of a cytokine such as IFN-gamma, or the expression of the costimulatory molecule B7.1 in the islets of Langerhans. Recent studies using this model have contributed to the u...Continue Reading

References

Sep 11, 1987·Cell·M B Oldstone
Dec 25, 1986·The New England Journal of Medicine·G C EbersT Grey
Jun 23, 1994·Nature·L L LauR Ahmed
Sep 1, 1994·The Journal of Clinical Investigation·C P GenainS L Hauser
Apr 1, 1995·Current Opinion in Immunology·J Sprent, S R Webb
Aug 1, 1995·Proceedings of the National Academy of Sciences of the United States of America·P B ChallonerM Chang
Mar 1, 1995·Immunology Today·A N Theofilopoulos
May 1, 1995·The Journal of Experimental Medicine·P Panina-BordignonF Sinigaglia
Jun 1, 1995·Clinical Immunology and Immunopathology·F SilvestrisF Dammacco
Jul 1, 1995·Proceedings of the Society for Experimental Biology and Medicine·C D Berdanier
Feb 1, 1995·The Journal of Clinical Investigation·M S LeeN Sarvetnick
Aug 1, 1994·Immunology Today·S D Miller, W J Karpus
Dec 1, 1994·Clinical Immunology and Immunopathology·K D Moudgil, E E Sercarz
Nov 1, 1994·The Journal of Experimental Medicine·K BankiA Perl
Dec 1, 1994·The Journal of Experimental Medicine·J D TaurogR E Hammer
Jan 1, 1994·Annals of Neurology·H S Panitch
Jun 1, 1994·The Journal of Experimental Medicine·L K SelinR M Welsh
Jan 18, 1994·Proceedings of the National Academy of Sciences of the United States of America·R Tisch, H O McDevitt
Jan 18, 1994·Proceedings of the National Academy of Sciences of the United States of America·P AicheleH Pircher
Mar 9, 1996·BMJ : British Medical Journal·B WagnerH Hofmann
May 3, 1996·Cell·R Tisch, H McDevitt
May 1, 1996·The Journal of Experimental Medicine·D KägiH Hengartner
Jun 1, 1996·The Journal of Experimental Medicine·F di Marzo VeroneseE Appella
Dec 1, 1995·Current Opinion in Immunology·T R Merriman, J A Todd

❮ Previous
Next ❯

Citations

Dec 18, 2001·European Journal of Immunology·S K SeoB S Kwon
Aug 26, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·A Cerny, F V Chisari
Mar 11, 1998·Current Opinion in Immunology·S Hausmann, K W Wucherpfennig
Oct 13, 2000·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·D P BogdanosD Vergani
May 15, 2001·Immunology and Cell Biology·M Regner
May 5, 2000·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·A J CzajaJ H Hoofnagle
Mar 29, 2001·Proceedings of the National Academy of Sciences of the United States of America·H S HiemstraB O Roep
Nov 25, 1998·Proceedings of the National Academy of Sciences of the United States of America·H ZhuT Shenk
Aug 15, 2001·Journal of the American Academy of Child and Adolescent Psychiatry·M Stocks
Nov 28, 2002·Journal of Pediatric Gastroenterology and Nutrition·Robert Pichler
Oct 7, 2006·Journal of Clinical Rheumatology : Practical Reports on Rheumatic & Musculoskeletal Diseases·Fernando DíazPilar Berdonces
Jul 21, 1998·Annals of the New York Academy of Sciences·D B DrachmanB Yang
Jun 14, 2000·Journal of Virology·M MeiteJ P Coutelier
Oct 9, 2002·Journal of Virology·Martin J RafteryGünther Schönrich
Mar 20, 2001·The Journal of Clinical Investigation·E KoustovaA S Basile
Dec 8, 2010·The Journal of Clinical Investigation·Pradyot DashPaul G Thomas
Sep 24, 2009·Blood·Elisa CantarelliLorenzo Piemonti
Nov 21, 1997·Emerging Infectious Diseases·J A Lindsay
Jun 16, 2014·Computational Biology and Chemistry·Tapati SarkarAshesh Nandy
Aug 19, 2000·Annals of Medicine·M G von Herrath, J L Whitton
Jun 3, 2009·Heart & Lung : the Journal of Critical Care·Burke A CunhaSara Nausheen
Mar 16, 2007·Journal of Autoimmunity·Roman Rieger, M Eric Gershwin
Mar 9, 2007·Journal of Theoretical Biology·Shingo IwamiTsuyoshi Kajiwara
Feb 20, 2003·Diabetes/metabolism Research and Reviews·Hee-Sook Jun, Ji-Won Yoon
Oct 8, 2013·Evolution; International Journal of Organic Evolution·Amy Hurford, Troy Day
Jun 13, 2006·Cellular Immunology·Xiao-Song HeM Eric Gershwin
Jun 29, 2012·Immunopharmacology and Immunotoxicology·Ana Carolina de AlmeidaAntonio Condino-Neto
Aug 24, 1999·European Journal of Immunology·H S HiemstraJ W Drijfhout
Sep 1, 2008·Expert Review of Clinical Immunology·Pietro InvernizziMauro Podda
Nov 6, 2001·The Journal of Biological Chemistry·Libby A BlairJohn A Corbett
May 5, 2010·Scandinavian Journal of Gastroenterology·Kar W LauBrian T Johnston
Aug 21, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Andrew GetahunJohn C Cambier

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

Related Papers

Immunological Reviews
M S Horwitz, N Sarvetnick
Journal of Pediatric Gastroenterology and Nutrition
S Guandalini
Journal of Theoretical Biology
Shingo IwamiMasahiro Yasukawa
© 2022 Meta ULC. All rights reserved