PMID: 9445023Jan 28, 1998Paper

Virus-induced cell motility

Journal of Virology
C M SandersonG L Smith

Abstract

Many viruses induce profound changes in cell metabolism and function. Here we show that vaccinia virus induces two distinct forms of cell movement. Virus-induced cell migration was demonstrated by an in vitro wound healing assay in which infected cells migrated independently into the wound area while uninfected cells remained relatively static. Time-lapse microscopy showed that the maximal rate of migration occurred between 9 and 12 h postinfection. Virus-induced cell migration was inhibited by preinactivation of viral particles with trioxsalen and UV light or by the addition of cycloheximide but not by addition of cytosine arabinoside or rifampin. The expression of early viral genes is therefore necessary and sufficient to induce cell migration. Following migration, infected cells developed projections up to 160 microm in length which had growth-cone-like structures and were frequently branched. Time-lapse video microscopy showed that these projections were formed by extension and condensation of lamellipodia from the cell body. Formation of extensions was dependent on late gene expression but not the production of intracellular enveloped (IEV) particles. The requirements for virus-induced cell migration and for the formation ...Continue Reading

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Citations

Dec 6, 2002·The Journal of General Virology·Geoffrey L SmithMansun Law
Feb 25, 2006·Traffic·Antonino SchepisJacomine Krijnse Locker
Nov 11, 2006·Proceedings of the National Academy of Sciences of the United States of America·Micah J WorleyFred Heffron
Oct 17, 2008·Nature Reviews. Microbiology·Quentin Sattentau
Oct 28, 2011·Journal of Virology·Anna C T C PereiraCláudio A Bonjardim
May 25, 2012·The Journal of General Virology·Virginie DoceulGeoffrey L Smith
May 18, 2006·Science's STKE : Signal Transduction Knowledge Environment·Sylvia MünterFreddy Frischknecht
Nov 12, 2005·Parasitology·I R Haga, A G Bowie
May 14, 2003·Journal of Virology·Susana GuerraMariano Esteban
Oct 7, 2003·Annual Review of Microbiology·Geoffrey L SmithMansun Law
Jul 14, 2010·Médecine sciences : M/S·Virginie DoceulGeoffrey L Smith
Apr 28, 2011·Nature Reviews. Microbiology·Matthew P TaylorLynn W Enquist
Jul 3, 2015·PLoS Pathogens·David J Pickup
Apr 3, 2020·Cellular Microbiology·Anjali GowripalanTimothy P Newsome
Nov 16, 2001·AIDS Research and Human Retroviruses·F J IbarrondoP Krogstad
Mar 7, 2009·The Journal of General Virology·Jens-Bernhard LoesingMichael Kleines
May 29, 2014·The Journal of General Virology·Zihao DengYi Pang
Jan 23, 2010·Science·Virginie DoceulGeoffrey L Smith
Jan 17, 2014·Journal of Virology·Ismar R HagaPhilippa M Beard
May 20, 2008·Traffic·Ivonne MoralesJacomine Krijnse Locker
Apr 29, 2011·Journal of Virology·Outi PaloheimoMaija Vihinen-Ranta
Jun 13, 2017·PloS One·Lidia Szulc-DąbrowskaMarek G Niemiałtowski
Nov 8, 2017·Integrative Biology : Quantitative Biosciences From Nano to Macro·Cheng WangZhi-Ling Zhang
Jun 8, 2001·News in Physiological Sciences : an International Journal of Physiology Produced Jointly by the International Union of Physiological Sciences and the American Physiological Society·Robert P. Stidwill, Urs F. Greber
Jun 8, 2007·The Journal of General Virology·Graham C FroggattPhilippa M Beard
Aug 31, 2018·Viruses·Scott ParkerRobert Mark Buller

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