Virus-induced neuronal apoptosis as pathological and protective responses of the host

Reviews in Medical Virology
Isamu MoriYoshinobu Kimura

Abstract

Extensive efforts have been made to elucidate mechanisms by which viruses induce apoptosis in cultured neuronal cells. However, little is yet understood about the mechanisms of neuronal apoptosis in vivo as well as interpretations of this active host response. Here we review recent advances toward understanding these topics. The c-Jun N-terminal protein kinase cascade may be an important apoptotic mediator in virally infected neurons, which comes in focus as a therapeutic target for protecting neurons from death. A novel concept can be proposed that virus-induced neuronal apoptosis in the central nervous system may represent a pathological host response, while that in the peripheral counterpart, especially olfactory receptor neurons, may mediate a protective host response.

Citations

Aug 18, 2012·Molecular Neurobiology·Giovanna De ChiaraAnna Teresa Palamara
Oct 15, 2013·Medicinal Research Reviews·Gordana TovilovicVladimir Trajkovic
Aug 27, 2005·Brain Research·Isamu MoriYukihiro Nishiyama
May 15, 2013·Microbes and Infection·Gordana TovilovicVladimir Trajkovic
Dec 1, 2009·Nature Reviews. Microbiology·Matthias J SchnellAmy Papaneri
Jul 23, 2005·Journal of Neurovirology·Isamu MoriYoshinobu Kimura
Jun 17, 2005·The Journal of General Virology·Patrick T W LawStephen K W Tsui
Aug 28, 2020·Frontiers in Cellular Neuroscience·Matija FenrichMarija Heffer
Sep 25, 2020·Journal of Neurochemistry·Isaias GlezerBettina Malnic

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis