Virus-infected peripheral blood plasmablasts in a patient with severe fever with thrombocytopenia syndrome.

International Journal of Hematology
Toru TakahashiHideki Hasegawa

Abstract

Severe fever with thrombocytopenia syndrome (SFTS) is a tick-borne viral hemorrhagic disease with a high fatality rate. It is caused by the SFTS virus and is endemic in East Asian countries such as China, South Korea, and Japan. Previous studies have shown that plasmablasts appear transiently in peripheral blood during the acute phase of SFTS, but do not specify the characteristics of these plasmablasts. In this report, we describe the features of peripheral blood plasmablasts in a patient with SFTS. Immunohistochemical and immunofluorescence staining detected a small number of atypical lymphocytes expressing the SFTS virus antigen among peripheral leukocytes in a blood sample. The phenotype of the virus-infected cells was CD27+, CD38+, MUM1+, and CD138+, which is consistent with that of plasmablasts. This novel study demonstrates that plasmablasts in the peripheral blood of patients with SFTS are targets of the SFTS virus.

References

Mar 18, 2011·The New England Journal of Medicine·Xue-Jie YuDe-Xin Li
Nov 12, 2013·Emerging Infectious Diseases·Kye-Hyung KimMyoung-don Oh
Nov 16, 2013·The Journal of Infectious Diseases·Toru TakahashiMasayuki Saijo
May 20, 2014·The Lancet Infectious Diseases·Quan LiuXing-Quan Zhu
Mar 3, 2017·Japanese Journal of Infectious Diseases·Taizo WadaAkihiro Yachie
Aug 2, 2019·Japanese Journal of Infectious Diseases·Kouji KidaToshio Kishimoto
Jan 7, 2020·The Journal of Clinical Investigation·Tadaki SuzukiHideki Hasegawa

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Citations

Jul 6, 2021·The Journal of Infectious Diseases·Yuji WadaTadaki Suzuki

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