PMID: 6166573Oct 15, 1980Paper

Virus infections and recurrence of osteosarcoma in patients receiving human leukocyte interferon

International Journal of Cancer. Journal International Du Cancer
S IngimarssonH Strander

Abstract

Human leukocyte interferon was given as adjuvant treatment for osteosarcoma in 26 patients. Blood from these patients was studied at regular intervals for antibodies to various micro-organisms. A continuous record of clinically manifest infections during the course of interferon therapy was made in 23 of the 26 patients. Distant metastases arose in 14 patients - the metastasis group. The report presents comparisons between these patients and the non-metastasis group. Seroconversion in tests with any of the studied micro-organisms was not common. Most of the seroconversions were not associated with clinical symptoms. Seroconversion during interferon therapy was confined to patients in the metastasis group. In some cases there was a chronologic link with early evidence of metastasis. The results of the serologic investigations are discussed and are correlated to the course of interferon therapy and of the neoplastic disease.

References

Jun 1, 1978·The Journal of General Virology·K Cantell, S Hirvonen
Jan 1, 1975·Annals of Internal Medicine·P S Schein, S H Winokur
Jan 1, 1976·International Journal of Radiation Oncology, Biology, Physics·D A Stevens, T C Merigan
Jan 1, 1977·Annual Review of Medicine·R F Betts, J B Hanshaw
Oct 1, 1979·The Journal of Infectious Diseases·S IngimarssonH Strander
Sep 18, 1977·Blut·H Strander
May 1, 1976·Clinical Immunology and Immunopathology·K AhoK Cantell
Jan 1, 1976·Drugs·N L Gerber, A D Steinberg
Sep 1, 1973·Journal of the National Cancer Institute·H StranderP A Jakobsson
Aug 1, 1974·The American Journal of the Medical Sciences·R FeldM Luna
Mar 9, 1967·The New England Journal of Medicine·G L StewartH M Meyer
Jul 12, 1965·JAMA : the Journal of the American Medical Association·E M HERSHE J FREIREICH
Feb 1, 1952·Proceedings of the Society for Experimental Biology and Medicine·A SVEDMYRA HOLLOWAY
Jan 1, 1949·Journal of General Microbiology·F FULTON, K R DUMBELL

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Citations

Jan 1, 1974·Scandinavian Journal of Immunology·H BlomgrenK Cantell
Aug 9, 2007·Cytokine & Growth Factor Reviews·Hans Strander

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