Jan 1, 1980

Virus inhibitory effect of combination of 9-(S)-(2,3-dihydroxypropyl) adenine and 6-azauridine

Chemotherapy
B Rada, A Holý

Abstract

Combination of 9-(S)-(2,3-dihydroxypropyl)adenine [(S)-DHPA] and 6-azauridine (AzUrd) is highly active in the selective inhibition of vaccinia virus in chick embryo cell culture. Synergic effect of this combination of compounds was not encountered in HeLa cell culture. Of the 17 analogues related to DHPA studied in this paper, 3 showed medium activity against vaccinia virus, but none of them was as effective as (S)-DHPA in combination with AzUrd.

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Mentioned in this Paper

Buffalopox virus
Azauridine
Vaccinia virus
Metabolic Inhibition
HeLa Cells
9-(2,3-dihydroxypropyl)adenine, (S)-isomer
Drug Augmentation
9-(2,3-dihydroxypropyl)adenine
9-(2,3-dihydroxypropyl)adenine, (R)-isomer
Adenine

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