PMID: 7525524Oct 1, 1994Paper

Virus isolate-specific antibodies against hypervariable region 1 of the hepatitis C virus second envelope protein, gp70

Japanese Journal of Cancer Research : Gann
N KatoK Shimotohno

Abstract

Hypervariable region 1 (HVR1), located in the N-terminal region of a putative second envelope glycoprotein (gp70) of hepatitis C virus (HCV), contains immunological B-cell epitopes which might be neutralizing epitopes. To clarify whether B-cell epitopes within HVR1 are common among virus isolates or specific for the homologous virus isolate, we examined the reactivities of sera from 53 patients with chronic hepatitis or hepatocellular carcinoma/liver cirrhosis against two different HVR1 peptides (HVR1 I-1 and HVR1 Y-1) derived from patient I with sporadic acute hepatitis and an asymptomatic carrier Y, respectively, using our original assay system for the detection of anti-HVR1 antibody. All patients examined had a history of blood transfusion. Most sera showed no reactivity with either HVR1 I-1 or HVR1 Y-1 peptide. Only seven and fourteen serum samples reacted significantly, although weakly, with HVR1 I-1 and HVR1 Y-1 peptides, respectively, compared with the serum from patient I or asymptomatic carrier Y. The blood transfusions of most reactive cases had occurred more than thirty years earlier. Six cases reacted with both HVR1 I-1 and HVR1 Y-1 peptides, but further analysis revealed that only three cases reacted weakly with th...Continue Reading

References

Apr 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·A J WeinerK A Crawford
Nov 30, 1992·Biochemical and Biophysical Research Communications·N KatoK Shimotohno
Aug 1, 1991·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M HoughtonQ L Choo
Nov 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·G InchauspeA M Prince
Oct 30, 1990·Biochemical and Biophysical Research Communications·K MuraisoK Shimotohno
Feb 28, 1991·Biochemical and Biophysical Research Communications·M HijikataK Shimotohno
Mar 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·Q L ChooP J Barr
Apr 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·N OgataR H Purcell
Sep 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·I SaitoY Ohta
Dec 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·N KatoK Shimotohno
Dec 1, 1993·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M KurosakiC Sato
Jan 15, 1994·International Journal of Cancer. Journal International Du Cancer·T NakazawaK Shimotohno

❮ Previous
Next ❯

Citations

May 22, 2003·Journal of Virological Methods·Laura RossiEnrico M Silini
Jan 4, 2001·Microbes and Infection·D R TaylorM M Lai
Mar 30, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·S J PolyakD R Gretch
Sep 29, 2001·The Journal of Peptide Research : Official Journal of the American Peptide Society·S Dueñas-CarreraJ Morales

❮ Previous
Next ❯

Related Concepts

Related Feeds

Carcinoma, Hepatocellular

Hepatocellular Carcinoma is a malignant cancer in liver epithelial cells. Discover the latest research on Hepatocellular Carcinoma here.