Virus-like particles from rabbit hemorrhagic disease virus can induce an anti-tumor response

Vaccine
Matthew PeaceyMargaret A Baird

Abstract

Recombinant virus-like particles (VLP) expressing heterologous tumor antigens have recently been investigated for use as vaccines. We have chemically conjugated ovalbumin (OVA) or OVA-derived CD4 (OTII) and CD8 (OTI) epitopes, to rabbit hemorrhagic disease virus (RHDV) VLP. VLP conjugated with OVA were able to cross-prime CD8+ cells from OT1 mice transgenic for the OVA T cell receptor. VLP.OTI was able to induce higher antigen-specific cytotoxicity in vivo than VLP mixed with either the protein or the peptide. Furthermore we have shown that the growth of the aggressive B16.OVA melanoma in mice was significantly delayed in those animals that had been vaccinated with VLP.OVA or with VLP coupled with both OTI and OTII peptides prior to the introduction of the tumor. Neither VLP.OTI nor VLP.OTII alone were capable of inhibiting tumor growth. This work suggests that RHDV VLP offer a versatile scaffold for multiple vaccine epitopes, enabling cross-presentation of the antigen to elicit potent cell-mediated and anti-tumor responses.

References

Jan 14, 1994·Cell·K A HogquistF R Carbone
Dec 22, 1998·The Journal of Experimental Medicine·K HungH Levitsky
May 1, 2001·Immunology·D M BrownE M Lord
Sep 19, 2003·Trends in Microbiology·Rob Noad, Polly Roy
Sep 24, 2004·Scandinavian Journal of Immunology·M BairdG Buchan
Nov 30, 2005·Journal of Pharmaceutical Sciences·Roxana M IonescuLi Shi
Apr 20, 2006·Vaccine·Sarah L YoungMargaret A Baird
Jun 5, 2007·Biotechnology and Bioengineering·Matthew PeaceyVernon K Ward

❮ Previous
Next ❯

Citations

Feb 14, 2012·Veterinary Research·Joana AbrantesPedro J Esteves
Jan 12, 2011·Immunology and Cell Biology·Stephanie J WinMargaret A Baird
Sep 10, 2015·Vaccines·Marie-Ève LebelAlain Lamarre
Jun 19, 2012·Veterinary Immunology and Immunopathology·Elisa CrisciMaría Montoya
Mar 6, 2012·Journal of Controlled Release : Official Journal of the Controlled Release Society·Sara J McKeeVernon K Ward
Sep 4, 2018·Expert Review of Vaccines·Braeden DonaldsonVernon K Ward
Aug 16, 2017·Journal for Immunotherapy of Cancer·Braeden DonaldsonSarah L Young
Feb 8, 2019·Journal of Immunology Research·Katrin KramerSarah L Young
Apr 4, 2021·Vaccines·Sasheen DowlathVernon K Ward
Sep 10, 2020·Asian Journal of Pharmaceutical Sciences·Lanxiang HuangFubing Wang

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cancer Vaccines

Cancer vaccines are vaccines that either treat existing cancer or prevent development of a cancer.