Virus receptors and tropism

Advances in Experimental Medicine and Biology
Aarthi Ashok, Walter J Atwood

Abstract

Polyomaviruses are small, tumorigenic, nonenveloped viruses that infect several different species. Interaction of these viruses with cell surface receptors represents the initial step during infection of host cells. This interaction can be a major determinant of viral host and tissue tropism. This chapter reviews what is currently known about the cellular receptors for each of five polyomavirus family members: Mouse polyomavirus (PyV), JC virus (JCV), BK virus (BKV), Lymphotropic papovavirus (LPV) and Simian virus 40 (SV40). These polyomaviruses serve to illustrate the enormous diversity of virus-cell surface interactions and allow us to closely evaluate the role of receptors in their life cycles. The contribution of other factors such as transcriptional regulators and signaling pathways are also summarized.

Citations

Apr 20, 2012·Journal of Virology·Thomas G MagaldiDaniel DiMaio
May 11, 2011·Expert Opinion on Biological Therapy·Chi-Fang ChangDeching Chang
Jul 18, 2015·Cancers·Raquel Burger-Calderon, Jennifer Webster-Cyriaque
Dec 25, 2017·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·T N CanavanB E Elewski
Aug 8, 2021·Cells·Etori Aguiar MoreiraPatrick Matthias

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