Virus-specific antibodies allow viral replication in the marginal zone, thereby promoting CD8(+) T-cell priming and viral control

Scientific Reports
Vikas DuhanKarl S Lang

Abstract

Clinically used human vaccination aims to induce specific antibodies that can guarantee long-term protection against a pathogen. The reasons that other immune components often fail to induce protective immunity are still debated. Recently we found that enforced viral replication in secondary lymphoid organs is essential for immune activation. In this study we used the lymphocytic choriomeningitis virus (LCMV) to determine whether enforced virus replication occurs in the presence of virus-specific antibodies or virus-specific CD8(+) T cells. We found that after systemic recall infection with LCMV-WE the presence of virus-specific antibodies allowed intracellular replication of virus in the marginal zone of spleen. In contrast, specific antibodies limited viral replication in liver, lung, and kidney. Upon recall infection with the persistent virus strain LCMV-Docile, viral replication in spleen was essential for the priming of CD8(+) T cells and for viral control. In contrast to specific antibodies, memory CD8(+) T cells inhibited viral replication in marginal zone but failed to protect mice from persistent viral infection. We conclude that virus-specific antibodies limit viral infection in peripheral organs but still allow repli...Continue Reading

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Citations

Oct 5, 2010·Ageing Research Reviews·Pierre-Olivier LangRichard Aspinall
Aug 18, 2016·Emerging Microbes & Infections·Jennifer LambourMireia Pelegrin
Nov 18, 2018·Clinical and Experimental Immunology·S-K FriedrichK S Lang
Aug 28, 2019·Proceedings of the National Academy of Sciences of the United States of America·Kai LiJürgen Ruland
Jan 26, 2021·Journal of Controlled Release : Official Journal of the Controlled Release Society·J GrabowskaJ M M den Haan
Sep 9, 2021·International Reviews of Immunology·Shane PrenzlerThomas Haselhorst

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Methods Mentioned

BETA
enzyme-linked immunosorbent assays
fluorescence-activated cell sorting
FACS

Software Mentioned

FlowJo

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