PMID: 6166723Jul 1, 1981Paper

Virus-specific interferon action. Protection of newborn Mx carriers against lethal infection with influenza virus

The Journal of Experimental Medicine
O HallerJ Lindenmann

Abstract

The efficacy of interferon in antiviral protection of newborn mice differing at the Mx locus was investigated. Adult mice bearing the allele Mx exhibit a high degree of specific resistance toward lethal challenge with influenza viruses. In contrast, newborn Mx carriers are virtually as susceptible to influenza viruses as newborn mice devoid of Mx. Resistance can be abrogated by treating adult animals with anti-interferon serum. Here, we provide direct evidence of a virus-specific effect of interferon in vivo: newborn mice carrying the resistance gene Mx could be protected against lethal influenza virus infection with doses of interferon that were not protective in the absence of Mx. The efficacy of interferon towards a picornavirus (encephalomyocarditis virus) and a rhabdovirus (vesicular stomatitis virus) was independent of Mx.

References

Mar 1, 1979·The Journal of Experimental Medicine·O HallerJ Lindenmann
Feb 1, 1973·Journal of Medical Microbiology·C McLaren, C W Potter
Jul 1, 1974·Proceedings of the Society for Experimental Biology and Medicine·M G ToveyI Gresser
Mar 13, 1980·Nature·E De Maeyer, J De Maeyer-Guignard
Jul 9, 1960·Lancet·A ISAACS, G HITCHCOCK
Jan 6, 1962·British Medical Journal·S BARON, A ISAACS
Jun 1, 1964·Proceedings of the Society for Experimental Biology and Medicine·J LINDENMANN

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Citations

Jan 1, 1983·Archives of Virology·H Arnheiter, P Staeheli
Jan 1, 1984·Pharmacology & Therapeutics·G C Sen
Jan 5, 2002·Theriogenology·M B Wheeler, E M Walters
Dec 4, 2003·Animal Reproduction Science·M B WheelerS G Clark
Feb 26, 2004·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Sarah L PoguePina M Cardarelli
Oct 1, 1987·Journal of Interferon Research·I Gresser
Jun 1, 1984·Antimicrobial Agents and Chemotherapy·P R WydeV Knight
Jan 18, 2008·Journal of Virology·Jan DittmannGeorg Kochs
Feb 26, 2005·Journal of Virology·Patty S Vernon, Diane E Griffin
Oct 14, 2011·Viruses·Paula M Pitha
Apr 12, 2007·Proceedings of the National Academy of Sciences of the United States of America·Daniel GrimmGeorg Kochs
Jan 13, 2009·European Journal of Immunology·Fabienne WillemsMark Suter
Jan 13, 2015·Trends in Microbiology·Otto HallerGeorg Kochs
Jan 24, 2015·Nature Reviews. Immunology·Finlay McNabAnne O'Garra
Dec 4, 2013·Microbiology and Molecular Biology Reviews : MMBR·Judith VerhelstXavier Saelens
Feb 6, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Timothy D CarrollChristopher J Miller
Aug 1, 1985·Molecular and Cellular Biology·P Staeheli, O Haller
Aug 20, 2010·Journal of Proteome Research·Rattiyaporn KanlayaVisith Thongboonkerd

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