Virus susceptibility and clinical effectiveness of anti-influenza drugs during the 2010-2011 influenza season in Russia

International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases
I A LenevaV V Maleev

Abstract

Antiviral drugs are critical adjuncts to influenza vaccination. This study determined the in vitro susceptibilities of influenza A and B viruses isolated in the 2010-2011 season in Russia to the neuraminidase inhibitor oseltamivir and the hemagglutinin fusion inhibitor umifenovir and clinical efficacy of this antiviral drugs in this season. The antiviral potency of these drugs against A(H1N1)pdm09 virus in mice was assessed. Importantly, the clinical effectiveness of oseltamivir and umifenovir was evaluated in a retrospective study conducted in 26 regions of Russia. All tested viruses (n=36) were susceptible to oseltamivir and umifenovir in vitro. Oseltamivir (10mg/kg/day) and umifenovir (60 mg/kg/day) significantly increased the survival of mice challenged with A/California/04/2009 (H1N1)pdm09 virus (p<0.05). Influenza infection was laboratory-confirmed in 442 patients among 1462 patients hospitalized with acute respiratory infections. The treatment of influenza-infected patients within 48h of symptom onset with oseltamivir and umifenovir was associated with a significant decrease in the duration of illness (2-3 days) and symptoms (p<0.001). Pneumonia was observed in none of the patients treated with oseltamivir and in 0.3% of...Continue Reading

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Citations

Feb 1, 2019·Journal of Virology·C E HulsebergJ M White
Nov 7, 2019·Microorganisms·Cristian-Marian PopescuMihnea Zdrenghea
May 15, 2020·Journal of Biomolecular Structure & Dynamics·Yusuke KatoKazuo Suzuki
May 17, 2019·Terapevticheskiĭ arkhiv·N Yu PshenichnayaI A Leneva
Jul 31, 2020·The Journal of Immunology : Official Journal of the American Association of Immunologists·Sergey A TarasovOleg I Epstein
Dec 23, 2016·Proceedings of the National Academy of Sciences of the United States of America·Rameshwar U Kadam, Ian A Wilson
Jul 11, 2018·Frontiers in Immunology·Meredith J CraneAmanda M Jamieson
Oct 25, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Laurita BoffStephan Ludwig
Dec 6, 2020·Medicinal Research Reviews·Jimin XuJia Zhou
Jan 5, 2021·Frontiers in Pharmacology·Bruno Silva AndradeVasco Ariston de Carvalho Azevedo
Nov 11, 2020·SN Comprehensive Clinical Medicine·Charu SonkarHem Chandra Jha
Dec 3, 2020·Frontiers in Microbiology·Shiu-Wan Chan
Feb 12, 2020·Cold Spring Harbor Perspectives in Medicine·John H Beigel, Frederick G Hayden

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