PMID: 7527632Jun 1, 1994Paper

Viruses and schizophrenia

The Australian and New Zealand Journal of Psychiatry
R L O'Reilly

Abstract

A viral hypothesis for the pathogenesis of schizophrenia has been under serious consideration for more than 70 years. To date, attempts have failed to identify a specific virus which contributes to the aetiology of the disorder. There has, however, been a recent resurgence of interest in a possible relationship between viral illness and schizophrenia. This renewed attention is the result of epidemiological evidence suggesting an excess of winter births in patients with schizophrenia, indications of foetal insults in persons who develop schizophrenia and an association between foetal exposure to the influenza virus and the subsequent development of schizophrenia. Advances in our understanding of the pathophysiology of viral diseases and the development of sophisticated techniques to study them have resulted in more complex viral hypotheses of schizophrenic aetiology, such as viral disruption of normal neurodevelopment, viral induced autoimmunity and retroviral integration. These hypotheses are now beginning to be tested experimentally.

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Citations

May 12, 2010·European Journal of Orthodontics·Alev CetinsahinSina Uçkan
Mar 3, 2005·CNS Drugs·Cheng LeeScott W Woods
Nov 29, 2002·American Journal of Medical Genetics·Lisa J PhillipsPatrick D McGorry
Jun 30, 2005·Journal of Psychiatric Practice·Lisa J PhillipsPatrick D McGorry

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