Viruses and the immune system: their roles in seizure cascade development

Journal of Neurochemistry
Daniel R GettsNicholas J C King

Abstract

Viral encephalitis affects approximately 7.5 people/100 000 and carries a high rate of morbidity and mortality. Most patients with viral encephalitis will develop some form of seizure during the infectious process, and of those who survive encephalitic disease, approximately 4-20% will develop epilepsy. Arthropod-borne (arbo)viruses are the leading cause of viral encephalitis in the world today, with between 10% and 35% of patients infected with these viruses displaying some form of seizure. Several neurotropic DNA viruses, including Herpes and cytomegalovirus also commonly cause seizures in infected patients. In the clinical setting, the cause of seizures seen during viral encephalitis is usually attributed to acute febrile responses. However, it has become apparent that the mechanisms behind seizure generation during viral encephalitis are likely to be much more complicated. For example, CD4(+) and CD8(+) T cells possibly through their secretion of interferon-gamma, appear to play an important role in determining neuronal responses when challenged with kainic acid. In addition, the ability of the human immunodeficiency virus, transactivating protein to modulate NMDA signaling possibly triggering seizures, highlights the fact ...Continue Reading

References

Feb 1, 1991·Journal of Neuroscience Research·W F HickeyH Kimura
Jan 1, 1984·Journal of Neurochemistry·F Fonnum
Apr 1, 1982·Journal of the Neurological Sciences·K KristenssonE Lycke
Jul 1, 1983·Acta paediatrica Scandinavica·M KoskiniemiO Pettay
Jan 1, 1994·Journal of Neuropathology and Experimental Neurology·R E Mrak, L Young
Sep 11, 1999·Neurochemistry International·M R Bennett, V J Balcar
Jan 14, 2000·Archives of Neurology·M WasayP Van Ness
Jul 13, 2001·Infectious Disease Clinics of North America·B A Cunha
Aug 3, 2001·Journal of Neurochemistry·N J HaugheyJ D Geiger
Sep 28, 2001·Journal of the Neurological Sciences·U K Misra, J Kalita
Sep 5, 2002·Journal of Medical Virology·Martin HäuslerLars Schaade
Jan 22, 2003·Brain & Development·Orvar Eeg-Olofsson
Mar 7, 2003·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·Cory TothJerome Yager
Mar 26, 2003·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Jason G NewlandKanta Subbarao
Aug 12, 2003·Cell Calcium·Mark Arundine, Michael Tymianski
Aug 21, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Tian WangErol Fikrig
Sep 10, 2003·Biochemical Pharmacology·Michelle M Aarts, Michael Tymianski
Nov 1, 1952·Electroencephalography and Clinical Neurophysiology·P D MACLEAN
Oct 4, 2003·Journal of Leukocyte Biology·Kate SchroderDavid A Hume
Dec 4, 2003·Journal of Virology·Yang WangArno Müllbacher
Dec 10, 2003·The Journal of Experimental Medicine·Michael S DiamondMichael Engle
Dec 23, 2003·The European Journal of Neuroscience·Hung-Ming WuKuei-Sen Hsu
Dec 24, 2003·Advances in Virus Research·Nicholas J KingAlison M Kesson
Mar 17, 2004·Progress in Neurobiology·Esther B E Becker, Azad Bonni

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Citations

Nov 20, 2010·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·N SpecchioF Vigevano
Jul 17, 2008·Epilepsia·William H TheodoreSteven Jacobson
Dec 17, 2009·Epilepsia·Kerry-Ann A StewartH Steve White
Aug 16, 2011·Epilepsia·Jainn-Jim LinKuang-Lin Lin
Apr 7, 2011·Experimental & Molecular Medicine·Chang Hoon Cho
Sep 4, 2013·Journal of Neuroimmunology·Suvi LiimatainenPeltola Jukka
Sep 20, 2011·Journal of the Neurological Sciences·Pornpun VivithanapornChristopher Power
Jun 3, 2008·Experimental Neurology·Harald H HofstetterHans-Peter Hartung
Jan 22, 2015·CNS Neuroscience & Therapeutics·Nina Dupuis, Stéphane Auvin
Oct 9, 2015·PloS One·Kuang-Lin LinUNKNOWN CHEESE Study Group
Dec 14, 2016·Journal of Neuroinflammation·Nina DupuisStéphane Auvin
Apr 25, 2018·Journal of Neurovirology·Ana Beatriz DePaula-SilvaRobert S Fujinami
Nov 22, 2020·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Xin XuXuefeng Wang

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