Viruses associated with human cancer.

Biochimica Et Biophysica Acta
Margaret E McLaughlin-Drubin, Karl Munger

Abstract

It is estimated that viral infections contribute to 15-20% of all human cancers. As obligatory intracellular parasites, viruses encode proteins that reprogram host cellular signaling pathways that control proliferation, differentiation, cell death, genomic integrity, and recognition by the immune system. These cellular processes are governed by complex and redundant regulatory networks and are surveyed by sentinel mechanisms that ensure that aberrant cells are removed from the proliferative pool. Given that the genome size of a virus is highly restricted to ensure packaging within an infectious structure, viruses must target cellular regulatory nodes with limited redundancy and need to inactivate surveillance mechanisms that would normally recognize and extinguish such abnormal cells. In many cases, key proteins in these same regulatory networks are subject to mutation in non-virally associated diseases and cancers. Oncogenic viruses have thus served as important experimental models to identify and molecularly investigate such cellular networks. These include the discovery of oncogenes and tumor suppressors, identification of regulatory networks that are critical for maintenance of genomic integrity, and processes that govern i...Continue Reading

References

Mar 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·G OrthG Rzesa
Mar 15, 1979·Nature·D P Lane, L V Crawford
Dec 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·M GreenP Rigden
Dec 1, 1976·Proceedings of the National Academy of Sciences of the United States of America·J K MackeyM Green
Aug 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·L J Zhao, C Z Giam
Jun 1, 1992·Molecular and Cellular Biology·W D FunkJ W Shay
May 8, 1992·Science·S E KernB Vogelstein
Jul 2, 1992·Nature·D P Lane
Jul 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·M ScheffnerP M Howley
Oct 1, 1990·Annals of Epidemiology·A S Evans, N E Mueller
Sep 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·A GessianD C Gajdusek
Sep 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·I SaitoY Ohta
Feb 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·A TanakaM Hatanaka
Oct 3, 1985·Nature·F Wong-Staal, R C Gallo
May 1, 1986·Molecular and Cellular Biology·E HarlowC Schley
Oct 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·D J McCanceL A Laimins
Sep 15, 1989·Biochemical and Biophysical Research Communications·D LaroccaT K Brunck
Mar 1, 1989·Journal of Virology·A TanakaY Ito
May 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·R GrassmannW A Haseltine
Oct 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·S E BearP N Tsichlis
Jun 15, 1988·International Journal of Cancer. Journal International Du Cancer·S Watanabe, K Yoshiike

❮ Previous
Next ❯

Citations

Oct 23, 2010·Medical Microbiology and Immunology·Martin MichaelisJindrich Cinatl
Jul 7, 2012·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Elen B BlochinHikmat Al-Ahmadie
Jan 27, 2010·Oncogene·A F Fernandez, M Esteller
Jan 5, 2012·Nanoscale·Abdulkadir YurtM Selim Ünlü
Apr 28, 2012·The Journal of Biological Chemistry·Claudio VillotaLuis O Burzio
Dec 3, 2011·Nucleic Acids Research·Xin ZhaoXiaoyan Zhang
Dec 14, 2011·QJM : Monthly Journal of the Association of Physicians·U RavnskovP J Rosch
Jan 15, 2014·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Winnie S LiangBradley J Monk
Jun 10, 2010·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·F LiuC Xiang
Jul 5, 2012·Evidence-based Complementary and Alternative Medicine : ECAM·Nor Hayati Othman
Oct 3, 2008·Cancer Research·Ronald T Javier, Janet S Butel
May 2, 2012·Cell Communication and Signaling : CCS·Christine Louis-Dit-SullyWolfgang W A Schamel
Jun 8, 2013·Virology Journal·Alma Mariana Fuentes-GonzálezMarcela Lizano
Sep 9, 2009·Virology Journal·Evgeny V VasilyevDenis V Rebrikov
May 26, 2010·Infectious Agents and Cancer·Valeria BergonziniGiorgio Palù
Jul 22, 2011·Epigenetics & Chromatin·Irina A MaksakovaMatthew C Lorincz
Oct 8, 2013·PLoS Computational Biology·Sven-Eric SchelhornFrank Berthold
Jan 10, 2014·AIDS·Paul G RubinsteinAndrew Zloza
Dec 7, 2013·Current Atherosclerosis Reports·Michael J Gonyeau
Aug 15, 2013·Cancer Letters·Scott A Read, Mark W Douglas
Jan 13, 2015·Frontiers in Biology·Young Bong Choi, Edward William Harhaj
Sep 24, 2015·Systems and Synthetic Biology·Zhao JinSusumu Goto
Jan 24, 2016·Jornal de pediatria·Vasileios BolisSophia Tsabouri
Dec 24, 2013·Advances in Chronic Kidney Disease·William S Asch, Margaret J Bia
Sep 2, 2015·Proceedings of the National Academy of Sciences of the United States of America·Abhik SahaErle S Robertson
Jul 24, 2012·Current Opinion in Virology·Janet S Butel, Hung Fan
Jun 19, 2012·Clinical Epigenetics·Elzbieta PorebaAnna Gozdzicka-Jozefiak
Jun 22, 2011·Clinics in Liver Disease·Romy ZemelRan Tur-Kaspa
Oct 2, 2009·Surgical Oncology Clinics of North America·Robert Gryfe
Oct 17, 2008·Cancer Letters·Emmanuel GarcionDidier Wion
Mar 28, 2009·Environmental and Molecular Mutagenesis·Anette DuensingStefan Duensing
Mar 30, 2011·International Journal of Cancer. Journal International Du Cancer·Felix Hoppe-Seyler, Karin Hoppe-Seyler
Jul 22, 2014·The Journal of Pathology·Takashi YamaguchiYuzuru Ikehara
Jan 24, 2014·Pathology Research International·Kanupriya Gupta, Rashmi Metgud
Dec 15, 2010·Trends in Biochemical Sciences·Norman E DaveyToby J Gibson
Apr 7, 2015·Seminars in Oncology·Brian J MorrisonDenise Whitby

❮ Previous
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