Viruses in the faecal microbiota of monozygotic twins and their mothers.

Nature
Alejandro ReyesJeffrey I Gordon

Abstract

Viral diversity and life cycles are poorly understood in the human gut and other body habitats. Phages and their encoded functions may provide informative signatures of a human microbiota and of microbial community responses to various disturbances, and may indicate whether community health or dysfunction is manifest after apparent recovery from a disease or therapeutic intervention. Here we report sequencing of the viromes (metagenomes) of virus-like particles isolated from faecal samples collected from healthy adult female monozygotic twins and their mothers at three time points over a one-year period. We compared these data sets with data sets of sequenced bacterial 16S ribosomal RNA genes and total-faecal-community DNA. Co-twins and their mothers share a significantly greater degree of similarity in their faecal bacterial communities than do unrelated individuals. In contrast, viromes are unique to individuals regardless of their degree of genetic relatedness. Despite remarkable interpersonal variations in viromes and their encoded functions, intrapersonal diversity is very low, with >95% of virotypes retained over the period surveyed, and with viromes dominated by a few temperate phages that exhibit remarkable genetic stab...Continue Reading

References

Jan 1, 1976·Annual Review of Biochemistry·C W Tabor, H Tabor
Dec 4, 1996·Biochemical and Biophysical Research Communications·X GarrigaP Reichard
Apr 3, 2001·Genome Research·D GordonP Green
Jul 24, 2001·BioTechniques·F RohwerF Azam
Dec 26, 2001·Nucleic Acids Research·Alex BatemanErik L L Sonnhammer
Apr 5, 2002·Twin Research : the Official Journal of the International Society for Twin Studies·Andrew C HeathPamela A F Madden
Oct 18, 2002·Proceedings of the National Academy of Sciences of the United States of America·Mya BreitbartForest Rohwer
Jan 10, 2003·Nucleic Acids Research·Daniel H HaftOwen White
Jul 31, 2003·Molecular Microbiology·Sherwood Casjens
Oct 4, 2003·Journal of Bacteriology·Mya BreitbartForest Rohwer
Feb 5, 2004·Genome Biology·Stefan KurtzSteven L Salzberg
Mar 23, 2004·Nucleic Acids Research·Robert C Edgar
Sep 21, 2005·Proceedings of the National Academy of Sciences of the United States of America·Hervé TettelinClaire M Fraser
Nov 9, 2006·PLoS Biology·Florent E AnglyForest Rohwer
Jan 24, 2007·Bioinformatics·Arthur L DelcherSteven L Salzberg
Jun 1, 2007·Nucleic Acids Research·Ibtissem GrissaChristine Pourcel
Jun 26, 2007·Applied and Environmental Microbiology·Qiong WangJames R Cole
Jul 10, 2007·Journal of Bacteriology·Roy David Magnuson
Sep 20, 2007·BMC Bioinformatics·Jeremiah J FaithRavi Sachidanandam
Sep 27, 2007·Environmental Microbiology·Gene W Tyson, Jillian F Banfield
Nov 28, 2007·Nucleic Acids Research·Robert D FinnAlex Bateman
Dec 14, 2007·Genome Research·Victor KuninPhilip Hugenholtz
Apr 10, 2008·PLoS Pathogens·Stacy R FinkbeinerDavid Wang
Jun 11, 2008·Research in Microbiology·Mya BreitbartForest Rohwer
Oct 23, 2008·Nucleic Acids Research·Lars J JensenChristian von Mering
Dec 2, 2008·Nature·Peter J TurnbaughJeffrey I Gordon
Mar 21, 2009·Nature Protocols·Rebecca V ThurberForest Rohwer
Apr 11, 2009·PLoS Computational Biology·James Robert WhiteMihai Pop
Apr 21, 2009·Molecular Biology and Evolution·Morgan N PriceAdam P Arkin
Jul 10, 2009·The ISME Journal·Vicente Gomez-AlvarezThomas M Schmidt
Aug 8, 2009·Environmental Microbiology·Florent AnglyForest Rohwer
Aug 28, 2009·Nature·Itai SharonOded Béjà
Oct 17, 2009·Nature Reviews. Microbiology·Francisco Rodriguez-ValeraAlex Mira
Feb 12, 2010·The ISME Journal·Beltran Rodriguez-BritoForest Rohwer
Apr 7, 2010·Proceedings of the National Academy of Sciences of the United States of America·Peter J TurnbaughJeffrey I Gordon
Apr 13, 2010·Nature Methods·J Gregory CaporasoRob Knight
May 7, 2010·The Journal of Biological Chemistry·Federico E ReyJeffrey I Gordon

❮ Previous
Next ❯

Citations

Nov 30, 2011·Diabetologia·J M Fernández-Real, J C Pickup
Apr 15, 2011·Applied Microbiology and Biotechnology·Damien Maura, Laurent Debarbieux
Feb 11, 2011·Current Infectious Disease Reports·Leslie H WardwellWendy S Garrett
Nov 18, 2011·Clinical Reviews in Allergy & Immunology·Graham A W Rook
Apr 12, 2013·Immunologic Research·Amy D ProalInge A Lindseth
May 7, 2013·Trends in Immunology·Yasmine BelkaidTimothy W Hand
Feb 1, 2011·Cellular & Molecular Immunology·Amy D ProalTrevor G Marshall
Jun 14, 2013·Clinical and Translational Gastroenterology·Vicente Pérez-BrocalAndrés Moya
Jul 29, 2010·The ISME Journal·Jeremiah J FaithJeffrey I Gordon
Mar 23, 2012·The ISME Journal·Clara Belzer, Willem M de Vos
Apr 20, 2013·The ISME Journal·Refugio Robles-SikisakaDavid T Pride
Sep 14, 2012·Nature·Catherine A LozuponeRob Knight
Jun 9, 2012·Nature Biotechnology·Rob KnightJack A Gilbert
Jan 27, 2011·Nature Communications·Xiaoxue WangThomas K Wood
Sep 17, 2013·Nature Communications·Lesley A OgilvieBrian V Jones
Jun 20, 2013·Nature Immunology·Yasmine Belkaid, Shruti Naik
Jun 20, 2013·Nature Immunology·Breck A Duerkop, Lora V Hooper
Apr 9, 2011·Nature Medicine·Elie Dolgin
Nov 10, 2010·Nature Reviews. Microbiology·Alan Walker
Jan 5, 2011·Nature Reviews. Microbiology·Marilyn J Roossinck
Aug 7, 2012·Nature Reviews. Microbiology·Alejandro ReyesJeffrey I Gordon
Dec 18, 2013·Biologie aujourd'hui·Laurent DebarbieuxDamien Maura
Mar 21, 2012·Proceedings of the National Academy of Sciences of the United States of America·Aya Brown KavItzhak Mizrahi
Feb 23, 2012·Proceedings of the National Academy of Sciences of the United States of America·Samuel MinotFrederic D Bushman
Mar 31, 2012·Proceedings of the National Academy of Sciences of the United States of America·Amber BenezraJeffrey I Gordon
Oct 10, 2012·Proceedings of the National Academy of Sciences of the United States of America·Breck A DuerkopLora V Hooper
Jul 10, 2013·Proceedings of the National Academy of Sciences of the United States of America·Samuel MinotFrederic D Bushman
Feb 8, 2013·Proceedings of the National Academy of Sciences of the United States of America·Sarah C P Williams
May 22, 2013·Proceedings of the National Academy of Sciences of the United States of America·Jeremy J BarrForest Rohwer
Nov 22, 2013·Proceedings of the National Academy of Sciences of the United States of America·Alejandro ReyesJeffrey I Gordon
Oct 11, 2012·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·Carlos F Amábile-Cuevas
Jul 4, 2013·The Journal of Infectious Diseases·Nikolay PopgeorgievChristelle Desnues
Dec 18, 2012·Molecular Biology and Evolution·Louis-Marie BobayMarie Touchon
Aug 13, 2011·Current Opinion in Clinical Nutrition and Metabolic Care·Sergueï O Fetissov, Pierre Déchelotte
May 11, 2012·Current Opinion in Gastroenterology·Michael Scharl, Gerhard Rogler
May 10, 2013·Current Opinion in Pediatrics·Erica M Carlisle, Michael J Morowitz
Sep 2, 2011·Genome Research·Samuel MinotFrederic D Bushman
Jun 8, 2012·Science·Lora V HooperAndrew J Macpherson
Aug 6, 2010·Science Translational Medicine·Daniel A Peterson, Peter J Turnbaugh
Apr 12, 2013·Science Translational Medicine·Andrew M PrenticeSophie E Moore
Sep 20, 2011·Applied and Environmental Microbiology·Kyoung-Ho Kim, Jin-Woo Bae
Oct 30, 2012·Applied and Environmental Microbiology·Shamayim T Ramírez-PueblaEsperanza Martínez-Romero

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Datasets Mentioned

BETA
GSM544865

Methods Mentioned

BETA
PCR
RNA-Seq
dissection
PCRs

Software Mentioned

tblastx
Minimo
454 Newbler assembler
Circonspect
Mummerplot
MaxiPhi
PHACCS Spectra
MySQL
Hit
PhageFinder

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