Visceral adiposity and high adiponectin levels are associated with the prevalence of pancreatic cystic lesions

International Journal of Obesity : Journal of the International Association for the Study of Obesity
Suguru MizunoKazuhiko Koike

Abstract

Obesity is increasing in developed countries and is a risk factor for pancreatic cancer (PaC). We previously reported that obesity was associated with pancreatic cystic lesions (PCLs), which are both precursors of, and risk factors for, PaC. In the present study, we further investigated the relationship between visceral adiposity and adiponectin levels and the extent of PCLs. Individuals who underwent comprehensive health screening at our institution between January 2008 and March 2013 were analyzed. PCLs were diagnosed via magnetic resonance imaging using a 3.0 Tesla system. The volumes of visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT) were measured from computed tomographic volume data. Serum levels of adiponectin were measured using a sandwich enzyme-linked immunosorbent assay. The prevalences of PCLs were 14.2% in males (N = 2683; mean age, 56.4 years) and 16.2% in females (N = 1741; mean age, 57.1 years). The prevalence of PCLs increased gradually as VAT volume increased (P < 0.001). PCLs were more prevalent in individuals with high adiponectin levels (18.7% vs. 13.8%, P = 0.005). VAT volume (odds ratio [OR] for the highest quartiles, 1.52 [1.07-2.16]; P = 0.025) and adiponectin level (OR for the highe...Continue Reading

References

Mar 27, 1999·Biochemical and Biophysical Research Communications·Y AritaY Matsuzawa
Nov 7, 2002·Circulation Journal : Official Journal of the Japanese Circulation Society·UNKNOWN Examination Committee of Criteria for 'Obesity Disease' in Japan, UNKNOWN Japan Society for the Study of Obesity
Dec 3, 2002·Nature Reviews. Cancer·Nabeel Bardeesy, Ronald A DePinho
Mar 12, 2003·The Journal of Clinical Endocrinology and Metabolism·Eleni PetridouDimitrios Trichopoulos
Apr 11, 2003·Archives of Surgery·Carlos Fernández-del CastilloAndrew L Warshaw
Apr 25, 2003·The New England Journal of Medicine·Eugenia E CalleMichael J Thun
Mar 6, 2004·The Journal of Clinical Endocrinology and Metabolism·Christos MantzorosDimitrios Trichopoulos
May 18, 2005·Endocrine Reviews·Takashi Kadowaki, Toshimasa Yamauchi
Jun 1, 2005·Urology·Serdar GoktasSelahattin Bedir
Jun 7, 2005·Expert Opinion on Therapeutic Targets·Herbert Tilg, Anna Maria Wolf
Nov 17, 2005·Journal of the National Cancer Institute·Esther K WeiChristos S Mantzoros
Jul 5, 2006·Journal of the National Cancer Institute·Tobias PischonElio Riboli
Mar 9, 2007·Clinica Chimica Acta; International Journal of Clinical Chemistry·Noriyuki Ouchi, Kenneth Walsh
Feb 13, 2008·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Douglas A CorleyWei Zhao
Mar 12, 2008·Pathophysiology of Haemostasis and Thrombosis·N InamiT Iwasaka
Apr 5, 2008·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Takamasa OhkiMasao Omata
Sep 20, 2008·American Journal of Epidemiology·Rachael Z Stolzenberg-SolomonDemetrius Albanes
Sep 17, 2009·The American Journal of Gastroenterology·Hyoun Woo KangIn Sung Song
Oct 20, 2009·Diabetes Care·Shuichiro YamamotoTetsuya Mizoue
Jan 29, 2010·Diabetes Care·UNKNOWN American Diabetes Association
Apr 1, 2010·The American Journal of Gastroenterology·Karen S LeeIvan Pedrosa
Jul 14, 2010·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Koen de JongMarco J Bruno
Jul 30, 2010·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Masahiro FujinoKeijiro Saku
Jun 18, 2011·International Journal of Cancer. Journal International Du Cancer·Verena A GroteRudolf Kaaks
Sep 6, 2011·Annals of Oncology : Official Journal of the European Society for Medical Oncology·D AuneT Norat
May 24, 2012·International Journal of Cancer. Journal International Du Cancer·Sabrina SchlesingerUte Nöthlings
Dec 18, 2012·Journal of the National Cancer Institute·Ying BaoBrian M Wolpin
May 2, 2014·Journal of Obesity·Mitsutaka NemotoKuni Ohtomo
Aug 12, 2014·BioMed Research International·Ersilia NigroAurora Daniele
Nov 14, 2014·Circulation Journal : Official Journal of the Japanese Circulation Society·Hiroshi YatsuyaAtsuko Aoyama
Dec 7, 2014·Annals of Oncology : Official Journal of the European Society for Medical Oncology·N KeumE L Giovannucci
Jul 17, 2015·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Masato NagaiUNKNOWN NIPPON DATA80/90/2010 Research Group
Oct 23, 2016·Oncotarget·Carla MicucciAlfonso Catalano
Jun 1, 2015·Annals of Oncology : Official Journal of the European Society for Medical Oncology·N KeumE L Giovannucci

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Citations

Nov 24, 2019·Journal of Gastroenterology and Hepatology·Hye Won ParkSungwon Park
Mar 4, 2021·Metabolic Syndrome and Related Disorders·Arthur Swislocki

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Methods Mentioned

BETA
enzyme-linked
ELISA

Software Mentioned

CT

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