Abstract
Lipid accumulation product (LAP) is a novel and effective index of visceral adiposity distribution based on waist circumference and triglycerides concentration. Few studies investigated the relationship between LAP and eGFR. We aimed to explore whether LAP was associated with declined renal function (eGFR < 60 mL/min/1.73m2), and also whether it exhibited obvious superiority in predicting kidney impairment compared with other obesity indices. In this cross-sectional study, 10,012 subjects were recruited from 22 sites in East China. LAP was calculated with the following formula: (WC-65) x TG for males, (WC-58) x TG for females. 4.7% participants with declined renal function had a higher LAP quartile. LAP was strongly associated with eGFR level (Beta: -0.073, P < 0.001) and declined renal function (P < 0.001) even after adjustment for age, sex, smoking, drinking, diabetes and hypertension. The risk of renal dysfunction increased 2.32-fold for the highest quartile LAP relative to the lowest quartile (OR: 2.32, 95%CI:1.52-3.53, P < 0.001). LAP exerted the largest area under the curve among different obesity indices (AUC ROC:0.644, 95%CI: 0.618-0.670, P < 0.001). Our findings showed that LAP strongly associated with declined renal f...Continue Reading
References
Apr 1, 1982·Radiology·J A Hanley, B J McNeil
Feb 13, 2001·Nutrition·D C FrankenfieldD Becker
Sep 24, 2004·The New England Journal of Medicine·Alan S GoChi-yuan Hsu
Sep 10, 2005·BMC Cardiovascular Disorders·Henry S Kahn
Feb 10, 2007·Kidney International·C KitiyakaraP Sritara
Dec 26, 2007·Hypertension·Sarah F KnightJohn D Imig
Feb 27, 2009·Diabetes Care·Stacy A PorterCaroline S Fox
Aug 7, 2009·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·M Mohsen Ibrahim
May 5, 2010·Advances in Chronic Kidney Disease·Olugbenga E Ayodele, C Olutayo Alebiosu
May 13, 2010·Lipids in Health and Disease·Mohammadreza BozorgmaneshFereidoun Azizi
Jan 8, 2011·Nephron. Clinical Practice·Rachel A NugentDorothy Chyung
Apr 30, 2011·Journal of the American Society of Nephrology : JASN·Francesca MallamaciUNKNOWN REIN Study Group
Sep 21, 2011·Hypertension·Meredith C FosterCaroline S Fox
Nov 19, 2011·Liver International : Official Journal of the International Association for the Study of the Liver·Jeong H KimChang H Lee
Jan 19, 2012·Renal Failure·Siren SezerNurhan Özdemir Acar
Mar 6, 2012·Lancet·Luxia ZhangHaiyan Wang
Jul 12, 2012·European Journal of Clinical Nutrition·C XiaQ Li
Feb 16, 2013·Medical Archives·Amina GodinjakZelija Velija-Asimi
Jun 26, 2013·The New England Journal of Medicine·Rena R WingSusan Z Yanovski
Sep 5, 2013·JAMA : the Journal of the American Medical Association·Yu XuUNKNOWN 2010 China Noncommunicable Disease Surveillance Group
Oct 5, 2013·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Davide Bolignano, Carmine Zoccali
Dec 7, 2013·Journal of Atherosclerosis and Thrombosis·Ichiro Wakabayashi, Takashi Daimon
May 6, 2014·The Lancet. Diabetes & Endocrinology·Aiko P J de VriesUNKNOWN ERA-EDTA Working Group Diabesity
Sep 1, 2015·Journal of Endocrinological Investigation·N MotamedF Zamani
Oct 22, 2015·Journal of Research in Medical Sciences : the Official Journal of Isfahan University of Medical Sciences·Ali MalekiElham Yousefi-Abdolmaleki
Oct 29, 2015·The Journal of Clinical Endocrinology and Metabolism·Ningjian WangYingli Lu
Nov 3, 2016·Journal of the American College of Nutrition·Azadeh MottaghiFereidoun Azizi
Feb 10, 2016·Annals of Internal Medicine·Yoosoo ChangEliseo Guallar
Apr 15, 2016·Human Reproduction·D MacutD Panidis
Sep 17, 2016·European Journal of Endocrinology·Ivana Božić-AntićDjuro Macut
Oct 28, 2016·The Journal of Biological Chemistry·Qing-Hua YinFang Liu
Dec 16, 2016·Journal of Diabetes·Hsin-Fang ChungChih-Cheng Hsu
Citations
Nov 18, 2019·Clinical and Experimental Nephrology·Pouria MousapourFarhad Hosseinpanah
Jul 24, 2020·Obesity Surgery·Amir I BassionyMohammed K Nassar
Mar 20, 2021·Diabetes, Metabolic Syndrome and Obesity : Targets and Therapy·Licui QiShuchun Chen
Jun 8, 2021·Diabetes, Metabolic Syndrome and Obesity : Targets and Therapy·Yang LiuYiming Mu
Oct 11, 2021·Lipids in Health and Disease·Pijun YanQin Wan