PMID: 7538319Jan 1, 1995Paper

Visceral endoderm-1 (VE-1): an antigen marker that distinguishes anterior from posterior embryonic visceral endoderm in the early post-implantation mouse embryo

Mechanisms of Development
T A Rosenquist, G R Martin

Abstract

We describe here an antigen marker, designated VE-1, that is detected early in gastrulation (approximately E6.5 through approximately E7.25) in the anterior visceral endoderm overlying the embryonic ectoderm opposite the primitive streak. The antibody-positive domain extends from the embryonic-extraembryonic junction to the distal tip of the embryo, and laterally around approximately one-third of the circumference of the egg cylinder. Analysis of embryos at earlier stages indicates that VE-1 is first expressed shortly after implantation, at approximately E5.0, in the visceral endoderm on one side of the embryo and thus is the earliest molecular marker of A-P asymmetry in the post-implantation mouse embryo described to date. Although VE-1 was detected with a polyclonal antiserum raised against a 24 amino acid polypeptide sequence of FGF2, we provide evidence that the VE-1 antigen is not FGF2. The data reported here are the first to provide molecular evidence that A-P polarity in the mouse embryo is established by E5.0 and that the visceral endoderm has A-P polarity.

Citations

Sep 23, 2003·Developmental Biology·Jaime A Rivera-PérezTerry Magnuson
Feb 17, 1998·Trends in Neurosciences·R G Northcutt, L A Barlow
Jul 24, 1998·Trends in Genetics : TIG·R S Beddington, E J Robertson
Feb 4, 1999·Annals of the New York Academy of Sciences·L A Barlow, R G Northcutt
Feb 23, 2012·Development·Claudio D Stern, Karen M Downs
Aug 18, 2009·Differentiation; Research in Biological Diversity·Romia HassounChristoph Viebahn
Mar 12, 2011·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Xenia Asbaek WolfPoul Hyttel
Jan 13, 2009·BMC Developmental Biology·Fiona C ManserghMartin J Evans
Mar 17, 1998·Developmental Biology·C BibenR P Harvey
Apr 20, 2007·Journal of Negative Results in Biomedicine·Pedro D Simões, Teresa Ramos
Aug 17, 2010·PloS One·Kemar BrownAnn Foley
Jan 16, 2009·PloS One·Camille Martinand-MariStephen Baghdiguian
May 3, 2008·Experimental Cell Research·David Hernández-GarcíaLuis Covarrubias
Aug 7, 2004·Developmental Cell·Janet Rossant, Patrick P L Tam
Feb 9, 2000·The Journal of Cell Biology·J HuelskenW Birchmeier
Jul 24, 2004·Seminars in Cell & Developmental Biology·Jan IdkowiakChristoph Viebahn
Jun 11, 2017·Cold Spring Harbor Perspectives in Biology·Joseph ZinskiMary C Mullins
Sep 27, 2003·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Elizabeth J RobertsonElizabeth K Bikoff
Nov 18, 1997·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·T Bouwmeester, L Leyns
Dec 18, 2020·Developmental Biology·Berna SozenMagdalena Zernicka-Goetz
Feb 12, 1998·Mechanisms of Development·P P Tam, R R Behringer
Feb 13, 1999·Cell·R S Beddington, E J Robertson

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.