Visceral Fat Is a Negative Determinant of Bone Health in Obese Postmenopausal Women

International Journal of Environmental Research and Public Health
Deepti K SharmaPeter M Clifton

Abstract

The protective effect of obesity on bone health has been challenged by studies that link visceral adiposity to poor bone microarchitecture in young obese men and women. In postmenopausal women, the role of visceral adipose tissue (VAT) on bone turnover markers (BTMs) has not been investigated. The aim was to investigate the impact of VAT on BTMs, total bone mineral density (BMD), vitamin D metabolites and parathyroid levels (1-84 PTH) levels in postmenopausal women. A total of 76 lean and overweight women (without osteoporosis) underwent VAT measurements by dual-energy X-ray absorptiometry (iDXA). Blood samples were analyzed for serum C-terminal telopeptide of type 1 collagen (CTX-1), osteocalcin, bone-specific alkaline phosphatase (bone ALP), 1-84 PTH and vitamin D (25 hydroxyvitamin D, 25(OH)D) levels. VAT volumes ranged from 91 to 3392 cm3 and body mass index (BMI) ranged from 18.3 to 53.9 kg/m2. Women in the highest VAT quartile had significantly lower CTX-1, 25(OH)D, osteocalcin and the highest BMD (p < 0.05, for all). While VAT positively associated with BMD, after controlling for BMI, VAT was a negative predictor of BMD (β = 0.368, p < 0.05). VAT was an independent negative predictor of CTX-1 (β = -0.263, p < 0.05) and o...Continue Reading

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Citations

Sep 2, 2020·Current Opinion in Clinical Nutrition and Metabolic Care·Andin Fosam, Rachel J Perry
Oct 20, 2020·Expert Review of Endocrinology & Metabolism·Mariangela ChiaritoMaria Felicia Faienza
Apr 6, 2021·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Ali K AlshabrawyPaul H Anderson

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Methods Mentioned

BETA
biopsies
X-ray
imaging techniques

Software Mentioned

iDXA Corescan
SPSS Stats
SPSS
CoreScan

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