Visceral hypersensitivity in functional disorders of the upper gastrointestinal tract

Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver
G SarnelliJan Tack

Abstract

Visceral hypersensitivity is now recognised as a major pathophysiological mechanism in functional gastrointestinal disorders of the upper gastrointestinal tract. In patients with non-cardiac chest pain and functional dyspepsia, a high prevalence of visceral hypersensitivity has been indeed observed. In these patients, luminal physiological stimuli can be perceived as unpleasant or even painful. Although the fine mechanisms underlying such "aberrant perceptions" are yet not fully clarified, it is thought that an altered activation of the gut-wall receptors, an altered conduction of sensory inputs at the level of neural pathways, or an impaired processing of the sensations at the level of brain, may occur along the brain-gut axis. So far, drugs able to reduce hypersensitivity, that target each of the constituents of the stimuli-perception chain, have the therapeutic potential to reduce visceral hypersensitivity and, thus, to improve the symptoms. In this context, the availability of new agonists/antagonists to neurotransmitters offers a new exciting tool for the treatment of functional disorders of the upper gastrointestinal tract.

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Citations

Nov 30, 2005·Current Gastroenterology Reports·Jan Tack, Sébastien Kindt
May 19, 2005·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·M Lancaster Smith
Apr 9, 2016·Gastroenterology Research and Practice·Yi-Zuo SongQing-Ke Huang
Jan 18, 2008·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·L Van OudenhoveJ Tack
Nov 23, 2012·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·X LiC H Wilder-Smith
Apr 23, 2014·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·R DickmanR Fass
Aug 21, 2013·Alimentary Pharmacology & Therapeutics·R IwakiriT Arakawa
Jul 30, 2015·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·F CarboneJ Tack
Apr 6, 2007·Gastroenterology·Georg DimcevskiAsbjørn M Drewes
Sep 4, 2009·Current Opinion in Gastroenterology·Jan Tack
Dec 13, 2006·Journal of Gastroenterology·Yohei MizutaShigeru Kohno
Mar 13, 2008·European Journal of Gastroenterology & Hepatology·Giovanni SarnelliRosario Cuomo

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