Visceral Kaposi's sarcoma remission after intestinal transplant. First case report and systematic literature review

Transplantation
Francesco D'AmicoGabriel E Gondolesi

Abstract

Kaposi's sarcoma (KS) is an infrequent vascular neoplasm commonly diagnosed as an isolated cutaneous lesion that can involve other organs. So far, there are no data in the literature about the development of KS after intestinal transplant. In this study, the authors describe a case of "visceral KS" with pulmonary and intestinal involvement and perform a systematic literature review of case reports and single-center series identified in MEDLINE. This case was a 42-year-old man, diagnosed with visceral KS 9 months after receiving an isolated intestinal transplant. He was successfully treated with a combination of sirolimus and liposomal doxorubicin and achieved an 18-month disease-free survival. A total of 54 cases from 27 manuscripts and the present case were analyzed in this study. The mean time from transplant to diagnosis was 17.2 months. Lungs and gastrointestinal tract were the main organs involved. Immunosuppressants were discontinued in two of the three (66.7%) cases, and sirolimus was added in eight cases. Doxorubicin was used in 12 cases. In a univariate analysis, the use of Tacrolimus, type of transplant, and presence of cutaneous KS seem to be the significant predictors of response to therapy and survival; the additio...Continue Reading

References

Aug 1, 1978·Cancer·J StriblingG V Smith
Aug 12, 1995·Lancet·N J LondonJ P Lodge
Aug 1, 1996·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·P S GillM E Ross
Jan 16, 1997·The New England Journal of Medicine·K E ForemanG J Nabel
Feb 4, 1997·Proceedings of the National Academy of Sciences of the United States of America·R MasoodP S Gill
Dec 1, 1996·The British Journal of Radiology·Z C TraillP J Shaw
Jun 1, 1997·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·F A ShepherdG Levy
Oct 6, 1997·Transplantation·I Penn
Apr 6, 2000·The New England Journal of Medicine·K Antman, Y Chang
Nov 9, 2000·The New England Journal of Medicine·J PaukL Corey
Aug 11, 2001·Transplantation Proceedings·M Lessan-PezeshkiM Mahdavi
May 1, 2002·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Soner DumanAli Başçi
May 10, 2002·The Journal of Infectious Diseases·Frank J JenkinsAngela Liegey-Dougall
Jun 22, 2002·Journal of the American Academy of Dermatology·Vincenzo RuoccoEleonora Ruocco
Dec 2, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Henry B KoonBruce J Dezube
Apr 1, 2005·The New England Journal of Medicine·Giovanni StalloneGiuseppe Grandaliano
Apr 26, 2005·Transplantation Proceedings·I BerberM I Titiz
May 28, 2005·Transplantation Proceedings·E BoeckleH Bonatti
Jun 30, 2005·Transplant Infectious Disease : an Official Journal of the Transplantation Society·G VerucchiM Bernardi
Oct 8, 2005·Transplantation·Dario CattaneoGiuseppe Remuzzi
Jun 9, 2006·The Journal of General Virology·S A Rahim RezaeeDavid J Blackbourn
Aug 25, 2006·International Journal of Cancer. Journal International Du Cancer·Sam M Mbulaiteye, Eric A Engels
Jan 9, 2007·BMC Neuroscience·Luc Tremblay, Digby Elliott
Apr 26, 2007·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Josep M Campistol, Francesco P Schena
Sep 8, 2007·Dermatology : International Journal for Clinical and Investigative Dermatology·Lilia Ben M'barekCéleste Lebbe
May 23, 2008·The American Journal of Dermatopathology·Dimitri SalameireSylvie Lantuejoul
Jul 29, 2008·Transplantation Reviews·Céleste LebbéCamille Francès
Dec 17, 2008·The British Journal of Dermatology·A DupuyC Lebbé

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Citations

Sep 13, 2012·Blood·Giovanni RivaLeonardo Potenza
Mar 8, 2013·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·J LeUNKNOWN AST Infectious Diseases Community of Practice
Mar 27, 2020·Pediatric Transplantation·Undine A GerlachGirish L Gupte

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