Viscoelastic behavior of osteoarthritic cartilage

Connective Tissue Research
F H SilverA Tria

Abstract

We have studied the incremental stress-strain behavior of human articular cartilage in tension in an attempt to understand the molecular basis for fibrillation and fissure formation in osteoarthritis. Our results indicate that the elastic spring constant for collagen in the direction per pendicular to the cleavage line pattern is about 1.6 GPa (2.3 GPa after correction for the collagen content) and the collagen fibril length is between 0.558 pm at low strains and 1.24 pm at high strains for normal cartilage. Values for the elastic spring constant and collagen fibril length were both found to decrease in OA. The value of the elastic spring constant for collagen perpendicular to the cleavage line pattern is similar to that calculated based on stress-strain curves reported by Kempson. Our results indicate that the elastic spring constant for collagen and the collagen fibril length decrease as the extent of fibrillation and fissure formation increase. Decreases in the elastic spring constant of collagen are consistent with loss of the superficial layer, degradation of proteoglycans and collagen, and subsequent mechanical fatigue. However, changes in the polymer volume fraction are consistent with enzymatic degradation preceding mec...Continue Reading

References

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Citations

Feb 20, 2002·Matrix Biology : Journal of the International Society for Matrix Biology·Frederick H SilverAlfred Tria
Dec 18, 2002·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·William J Landis, Frederick H Silver
Apr 11, 2003·Connective Tissue Research·Frederick H SilverPatrick B Snowhill
Sep 30, 2008·Biochemical and Biophysical Research Communications·Ronald K June, David P Fyhrie
Mar 4, 2006·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Rajesh K UthamanthilMark D Markel
Dec 8, 2004·Matrix Biology : Journal of the International Society for Matrix Biology·Frederick H SilverAlfred Tria
Mar 13, 2010·Annals of Biomedical Engineering·David M PierceGerhard A Holzapfel

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