Viscoelastic haemostatic assays and fibrinogen in paediatric acute traumatic coagulopathy: A comprehensive review.

Emergency Medicine Australasia : EMA
Sharon MaconachieShane George

Abstract

Haemorrhage in paediatric trauma remains a significant cause of morbidity and mortality. Over recent years there has been increasing attention to the role of fibrinogen in traumatic haemorrhage and the association of low fibrinogen levels with poor patient outcomes. In addition, there has been a move towards using viscoelastic haemostatic assays (VHAs) to rapidly assess coagulation status and guide clinicians in the replacement of coagulation factors, including fibrinogen. In the paediatric population, there has been limited uptake of these principles and a paucity of data to support a change in practice. This paper summarises the available evidence in the published literature through a systematic review, presented in narrative format. There is limited high-quality prospective data on the use of VHA in the management of acute traumatic coagulopathy in the paediatric population. While the use of fibrinogen early in major haemorrhage is becoming standard practice, there are currently no randomised prospective studies comparing fibrinogen concentrate to cryoprecipitate. The early identification of hypo-fibrinogenemia and acute traumatic coagulopathy in paediatric trauma using VHA testing and subsequent early fibrinogen replacement...Continue Reading

References

Aug 1, 1995·Anesthesia and Analgesia·S T HiippalaE M Vahtera
Jun 19, 2003·The Journal of Trauma·Karim BrohiTimothy Coats
Nov 17, 2006·British Journal of Haematology·UNKNOWN British Committee for Standards in HaematologyP J Hamilton
Feb 23, 2008·Anesthesia and Analgesia·Thorsten HaasPetra Innerhofer
Oct 14, 2008·The Journal of Trauma·John R HessBertil Bouillon
Jun 25, 2010·Transfusion·Wayne L ChandlerSuzanne Moody
Jul 16, 2010·British Journal of Anaesthesia·D Fries, W Z Martini
Mar 8, 2011·Critical Care : the Official Journal of the Critical Care Forum·Herbert SchöchlCristina Solomon
Jul 7, 2011·Cardiology in the Young·Jo Bønding AndreasenHanne Berg Ravn
Jul 19, 2011·Critical Care Medicine·Ross DavenportKarim Brohi
Sep 20, 2011·The Journal of Pediatrics·Jeanne E HendricksonCassandra D Josephson
Sep 20, 2011·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Jason T PatregnaniPhilip C Spinella
Oct 4, 2011·Anesthesia and Analgesia·Jerrold H LevyRoman M Sniecienski
Oct 18, 2011·Critical Care : the Official Journal of the Critical Care Forum·Sibylle Kozek-LangeneckerDonat R Spahn
Oct 25, 2011·British Journal of Haematology·Ross Davenport, Sirat Khan
Nov 15, 2011·Critical Care : the Official Journal of the Critical Care Forum·Herbert SchöchlCristina Solomon
Dec 2, 2011·Transfusion·Jeanne E HendricksonCassandra D Josephson
Sep 12, 2012·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Bernhard ZieglerCristina Solomon
Oct 16, 2012·The Journal of Trauma and Acute Care Surgery·Sara J ChidesterJonathan I Groner
Feb 26, 2013·British Journal of Haematology·Yaser A DiabNaomi L C Luban
May 10, 2013·European Journal of Anaesthesiology·Sibylle A Kozek-LangeneckerPiet Wyffels
Aug 15, 2013·The Journal of Trauma and Acute Care Surgery·John B HolcombUNKNOWN PROMMTT Study Group
Jul 13, 2013·Journal of Pediatric Surgery·Adam M VogelBryan A Cotton
Nov 23, 2013·Current Opinion in Anaesthesiology·Kenichi A TanakaKlaus Görlinger
Feb 27, 2014·Shock·Sarah C ChristiaansJean-François Pittet
Mar 29, 2014·Critical Care : the Official Journal of the Critical Care Forum·Jostein S HagemoChristine Gaarder
Jul 26, 2014·Acta Anaesthesiologica Scandinavica·J LundeA Afshari
Apr 17, 2015·Critical Care : the Official Journal of the Critical Care Forum·Giuseppe NardiGiulia Ranaldi
Apr 19, 2015·Critical Care : the Official Journal of the Critical Care Forum·Jostein S HagemoChristine Gaarder
Apr 19, 2015·Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine·Kristin Brønnum NystrupSisse R Ostrowski
May 21, 2015·British Journal of Anaesthesia·N CurryS Stanworth
Jan 29, 2016·British Journal of Haematology·Gregory A Hans, Martin W Besser
Apr 14, 2016·Critical Care : the Official Journal of the Critical Care Forum·Rolf RossaintDonat R Spahn
Jun 30, 2016·Scandinavian Journal of Clinical and Laboratory Investigation·Cristina SolomonDonat R Spahn
Sep 17, 2016·Anesthesia and Analgesia·James WinearlsJohn F Fraser
Dec 14, 2016·British Journal of Anaesthesia·B NascimentoA Beckett
Mar 18, 2017·Seminars in Pediatric Surgery·Christine M Leeper, Barbara A Gaines
May 10, 2017·The Journal of Trauma and Acute Care Surgery·Jeremy W CannonLucas P Neff

❮ Previous
Next ❯

Citations


❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.