Viscoelastic properties of cartilage-subchondral bone complex in osteoarthritis

Journal of Medical Engineering & Technology
A P FortisA Kokkinos

Abstract

This study examines viscoelastic properties of the 'unaffected' tibial condyle in unicompartmental osteoarthritic knees, in order to determine whether to preserve it or not in knee replacement operations. The viscoelastic properties of longitudinal strips of cartilage and subchondral bone from osteoarthritic and healthy knees were studied. Nine medial compartment osteoarthritic and nine cadaveric knees, all age- and gender-matched, were studied. Samples from polyethylene and methacrylate cement were also obtained and all then tested in the DMA (Dynamic Mechanical Analysis) testing apparatus. The dynamic modulus of elasticity (E(dyn)) and the loss factor (tan delta) were measured. The medial compartment in osteoarthritic knees had lost its viscoelastic properties, having a significantly higher E(dyn) compared to the lateral one, and lower values of loss factor. In healthy knees there was no significant difference (p=0.18) in viscoelastic properties between both compartments and with the unaffected side of the osteoarthritic knee. Polyethylene and cement appear to have a high modulus of elasticity compared to both the healthy and the osteoarthritic knees. The 'unaffected' (lateral) tibial condyles in medial compartment osteoarthr...Continue Reading

References

Jul 1, 1994·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·L A SettonD S Howell
Jul 1, 1994·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·F GuilakV C Mow
May 1, 1994·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·K A AthanasiouF J Dzida

❮ Previous
Next ❯

Citations

Aug 10, 2011·Journal of Biomechanical Engineering·Nicolas V JaumardBeth A Winkelstein
Jun 6, 2009·BMC Musculoskeletal Disorders·Geoffrey R FulcherDuncan E T Shepherd
Jul 9, 2013·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Kazuya IkomaToshikazu Kubo
Mar 18, 2008·Clinical Biomechanics·Koji NagasawaToshikazu Kubo
Mar 15, 2015·Proceedings of the Institution of Mechanical Engineers. Part H, Journal of Engineering in Medicine·Hamid SadeghiDuncan E T Shepherd
Apr 12, 2013·Biomechanics and Modeling in Mechanobiology·Liming ZhaoHiroki Yokota
Jan 20, 2011·Bioinspiration & Biomimetics·Sang-Hee Yoon, Sungmin Park
Apr 5, 2008·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Leah C AbrahamDavid L Kaplan
Sep 13, 2017·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Derek T HolyoakMarjolein C H van der Meulen
Jul 22, 2014·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Christian EgloffMagdalena Müller-Gerbl
Nov 20, 2013·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Harri T KokkonenJuha Töyräs
Sep 30, 2020·Expert Opinion on Drug Discovery·Carley OrtChristopher Moraes

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.