Viscoelastic properties of collagen: synchrotron radiation investigations and structural model

Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
R PuxkandlP Fratzl

Abstract

Collagen type I is the most abundant structural protein in tendon, skin and bone, and largely determines the mechanical behaviour of these connective tissues. To obtain a better understanding of the relationship between structure and mechanical properties, tensile tests and synchrotron X-ray scattering have been carried out simultaneously, correlating the mechanical behaviour with changes in the microstructure. Because intermolecular cross-links are thought to have a great influence on the mechanical behaviour of collagen, we also carried out experiments using cross-link-deficient tail-tendon collagen from rats fed with beta-APN, in addition to normal controls. The load-elongation curve of tendon collagen has a characteristic shape with, initially, an increasing slope, corresponding to an increasing stiffness, followed by yielding and then fracture. Cross-link-deficient collagen produces a quite different curve with a marked plateau appearing in some cases, where the length of the tendon increases at constant stress. With the use of in situ X-ray diffraction, it was possible to measure simultaneously the elongation of the collagen fibrils inside the tendon and of the tendon as a whole. The overall strain of the tendon was alway...Continue Reading

References

Jan 1, 1989·Connective Tissue Research·P F Davison
Apr 20, 1985·Journal of Molecular Biology·E MoslerM H Koch
Mar 14, 1972·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·J DiamantR G Arridge
Jan 1, 1984·Annual Review of Biochemistry·D R EyreP M Gallop
Jan 1, 1982·Methods in Enzymology·N D Light, A J Bailey
Jun 1, 1980·The American Journal of Occupational Therapy : Official Publication of the American Occupational Therapy Association·J Poole, M M Parkinson
May 1, 1995·Biophysical Journal·D J HulmesP Fratzl
Sep 2, 1998·Journal of Structural Biology·P FratzlS Bernstorff
Jan 12, 1999·Mechanisms of Ageing and Development·A J BaileyL Knott
May 1, 1964·Proceedings of the National Academy of Sciences of the United States of America·J A PETRUSKA, A J HODGE

❮ Previous
Next ❯

Citations

Sep 29, 2007·Biomechanics and Modeling in Mechanobiology·Michael LavagninoRoger C Haut
Jun 4, 2010·Biomechanics and Modeling in Mechanobiology·Fang YuanL Catherine Brinson
Nov 12, 2010·Biomechanics and Modeling in Mechanobiology·Marc HollensteinEdoardo Mazza
Sep 1, 2005·Annals of Biomedical Engineering·Hazel R C ScreenDavid A Lee
Jul 17, 2007·Annals of Biomedical Engineering·Gail M ThorntonThomas R Oxland
May 18, 2013·Bulletin of Mathematical Biology·Mark S Thompson
Sep 11, 2012·Advanced Drug Delivery Reviews·Ensanya A Abou NeelJung Keun Hyun
Dec 21, 2004·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Carlos Bonifasi-ListaJeffrey A Weiss
Dec 18, 2002·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Peter P Purslow
Sep 1, 2010·Animal : an International Journal of Animal Bioscience·K L GohT J Wess
Jan 15, 2014·BoneKEy Reports·Ming Fang, Mark M Banaszak Holl
Jan 9, 2013·The Journal of Biological Chemistry·Preety PanwarDieter Brömme
Nov 13, 2012·Computer Methods in Biomechanics and Biomedical Engineering·Facundo J BellomoLiz G Nallim
Aug 19, 2007·Journal of the Royal Society, Interface·Helmut O K Kirchner, Markus Lazar
Dec 25, 2008·Journal of the Royal Society, Interface·P Ciarletta, M Ben Amar
Jul 3, 2009·Journal of the Royal Society, Interface·Maria Grazia OrtoreDaniela Russo
Jul 6, 2012·Journal of the Royal Society, Interface·Chavaunne T ThorpeHazel R C Screen
Sep 3, 2010·Proceedings. Biological Sciences·Zuoqi ZhangHuajian Gao
Jun 8, 2004·Journal of Biomechanical Engineering·Preethi L Chandran, Victor H Barocas
Jul 8, 2008·Journal of Biomechanical Engineering·T D NguyenB L Boyce
Jan 22, 2009·Journal of Biomechanical Engineering·Blayne A RoederSherry L Voytik-Harbin
May 13, 2010·Journal of Biomechanical Engineering·Thomas L WillettJ Michael Lee
Oct 10, 2008·The European Physical Journal. E, Soft Matter·S UlrichA Zippelius
Apr 10, 2010·Journal of Applied Physiology·Laurie GumezChantal Pichon
Dec 17, 2008·Journal of Applied Physiology·Trevor J LujanJeffrey A Weiss
Aug 10, 2006·Proceedings of the National Academy of Sciences of the United States of America·Markus J Buehler
Feb 20, 2014·Journal of the Mechanical Behavior of Biomedical Materials·Bingbing AnDongsheng Zhang
Dec 4, 2014·Journal of Biomechanics·Brianne K ConnizzoLouis J Soslowsky
Feb 18, 2014·Acta Biomaterialia·Spencer E Szczesny, Dawn M Elliott
Apr 2, 2011·Connective Tissue Research·René B SvenssonStig P Magnusson
Jul 29, 2009·Connective Tissue Research·Philip HansenPeter Magnusson
Dec 14, 2007·Connective Tissue Research·Takafumi WatanabeKazushige Takehana
Oct 30, 2004·Connective Tissue Research·Joseph W Freeman, Frederick H Silver
Apr 15, 2010·Connective Tissue Research·Diego F Villegas, Tammy L Haut Donahue
Jul 11, 2012·Connective Tissue Research·Preethi L ChandranJeffrey W Holmes
Mar 2, 2016·Journal of the Mechanical Behavior of Biomedical Materials·Mahan QwamizadehYong Wei Zhang
Dec 26, 2012·Journal of the Mechanical Behavior of Biomedical Materials·Federico BosiaNicola M Pugno
Jun 2, 2012·Medical Engineering & Physics·H R C ScreenJ C Shelton
Dec 30, 2011·Matrix Biology : Journal of the International Society for Matrix Biology·Alfonso GautieriMarkus J Buehler
Jan 17, 2012·Journal of Shoulder and Elbow Surgery·Gion FesselJess G Snedeker

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.